Association between placental (pro)renin receptor and small for gestational age in Pre-eclmpsia.

Objective:- Study the association between placental (Pro) renin receptor with the severity of pre-eclampsia and incidence of small for gestational age birth weight. Method:- 60 pairs of (pre-eclamptic pregnant women and their newborns) admitted to the labour ward with singleton pregnancy, gestational age from 36th to 40th weeks, pregnant women age range between (20-40) years. Exclusion criteria were any abnormalities of placenta, structural anomalies in the fetus, multiple pregnancy. The subjects in this study were divided into two main groups: First group contain 30 pairs of pre- eclamptic patients with small for gestational age term newborns. Second group contain 30 pairs of Pre- eclamptic patients with appropriate for gestational age term newborns. Among these Pre-eclamptic women 32 of them were had severe pre-eclampsia and 28 of them were with mild pre-eclampsia. Result:- The mean of placental (Pro) renin receptor in severe pre-eclampsia was significantly higher (91.4 ng/ml) than the mean of placental (Pro) renin receptor in mild pre-eclampsia (77.54ng/ml) ( Pvalue 0.0001). The results shown that the mean of placental (P)RR in pre-eclamptic women with (SGA) newborns was (88.44 ng/ml) and it was significantly higher (P value 0.002) than that of the pre-eclamptic women with (AGA) newborns (81.43 ng/ml). Conclusion:- High placental (P)RR concentration associated with increased severity of pre-eclampsia and high (SGA) birth likelihood.