31May 2016

PROGNOSTIC RELEVANCE OF TUMOR NECROSIS FACTOR ALPHA (TNF-?) IN ACUTE MYELOID LEUKEMIA (AML).

  • Assistant Professor, University of Health Sciences, PGIMS, Rohtak, Dept. of Biochemistry, Haryana, India, 124001.
  • Professor & Head, University of Health Sciences, PGIMS, Rohtak, Dept. of Biochemistry, Haryana.
  • Assistant Professor, Department of Biochemistry, BPS GMC for Women, KhanpurKalan, Sonepat, Haryana.
  • Demonstrator, University of Health Sciences, PGIMS, Rohtak, Dept. of Biochemistry, Haryana.
  • Professor & Head, University of Health Sciences, PGIMS, Rohtak, Dept. of Medicine, Haryana.
  • Demonstrator, University of Health Sciences, PGIMS, Rohtak, Dept. of Blood and Transfusion Medicine, Haryana.
  • Medical officer, GH Mandikhera, Mevat, Haryana.
  • Demonstrator, University of Health Sciences, PGIMS, Rohtak, Dept. of Biochemistry, Haryana.
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Levels of Tumor Necrosis Factor alpha (TNF,cachexin or cachectin and formerly known as tumor necrosis factor alpha) a cytokine involved in systemic inflammation was studied in 30 newly diagnosed AML patients before and after 4 week combination chemotherapy of cytarabine and an anthracycline (daunorubicin), APL patients were treated with tretinoin plus concurrent anthracycline chemotherapy followed by maintenance therapy with either tretinoin or chemotherapy. 30 age and sex matched healthy controls were taken. The present study was conducted in the department of Biochemistry in collaboration with Department of Medicine (Clinical Hematology Unit); Pt. B. D. Sharma PGIMS,Rohtak. TNF levels at diagnosis were significantly higher in patients not achieving remission than levels in patients achieving remission (p=0.015).Levels of TNF decreased significantly after therapy only in remission group.

[DokwalS, Ghalaut VS, Bansal P, Kumari A, Ghalaut PS, Singh R, Prakash G and Mahor D. (2016); PROGNOSTIC RELEVANCE OF TUMOR NECROSIS FACTOR ALPHA (TNF-?) IN ACUTE MYELOID LEUKEMIA (AML). Int. J. of Adv. Res. 4 (May). 865-870] (ISSN 2320-5407). www.journalijar.com

Sumit Dokwal

DOI:

Article DOI: 10.21474/IJAR01/439      
DOI URL: https://dx.doi.org/10.21474/IJAR01/439

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