ACETYLSALICYLIC ACID (ASA) IMPAIRS INFLUENZA B VIRUS PROPAGATION AND DELAY APOPTOSIS IN INOCULATED A549 AND MDCK II CELL LINES.
- Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat City 32897, Egypt.
- Faculty of Medicine, Al-Azhar University, Cairo 35527, Egypt.
- Central Public Health Laboratories (CPHL), Cairo 11613, Egypt.
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Despite the increasing knowledge in the influenza virus host interactions, most of the published work focuses on influenza A viruses, leaving a gap with respect to influenza B virus host interactions , Here we examined acetylsalicylic acid (ASA), also known as aspirin, on A549 and MDCKII cells infected by INF B Yamagata virus ,and the anti-NF-kB and anti-influenza virus action of ASA were studied ,our results show that a few millimolar concentration range from ASA which do not affect the viability of cultured cells, can impaired INF B virus propapagation and playing a role in delaying apoptosis via impaired TNF? induced NF-?B signaling.
[Khalid Bassiouny, Ibrahim El-Sayed, Aziz Nokaly, Ahmed S. Abdelghani and Wael Roshdy. (2016); ACETYLSALICYLIC ACID (ASA) IMPAIRS INFLUENZA B VIRUS PROPAGATION AND DELAY APOPTOSIS IN INOCULATED A549 AND MDCK II CELL LINES. Int. J. of Adv. Res. 4 (May). 1247-1257] (ISSN 2320-5407). www.journalijar.com
