TO EVALUATE THE STATUS OF SERUM VITAMIN D IN CHRONIC MYELOID LEUKEMIA.

Introduction: Recently data accruing has suggested some links between Vit D and occurrence of Cancer. Studies have presented controversial results. So this study was planned to analyze the link between Vit D and Chronic Myeloid Leukemia. Aims and objectives: 1. To evaluate the status of serum vitamin D, in twenty five diagnosed CML patients. 2. To compare the status of serum vitamin D, with twenty five age and sex matched healthy controls. Patients and controls were categorized into two groups. Group I: Diagnosed cases with CML. Group II: Control group- age and sex matched healthy volunteers. Material and methods: In this present study twenty five patients of diagnosed CML and twenty five age and sex matched healthy controls were enrolled for the study. The diagnosis in cases was made by history, clinical examination, total and differential leukocyte count, bone marrow examination and cytogenetic studies. Serum vitamin D levels were estimated by a commercial enzyme linked immunosorbent assay kit for human vitamin D Results and observations:In the present study mean serum vitamin D level in group I was 23.04±7.95 ng/ml. In group II, mean serum vitamin D level was 23.75±8.65 ng/ml (range 8.07 to 44.11 ng/ml). In males, mean serum vitamin D level in group I was 24.5±8.5 ng/ml and in group II 24.3±10.7 ng/ml. In females, mean serum vitamin D level in group I was 21.9±7.5 ng/ml and in group II 23.2±7.0 ng/ml. Conclusion:There was no significant correlation observed between Vit D levels and CML.