IMPLICATION OF TRICLOSAN AS AN ANTI-CYTOKINE DRUG IN CHRONIC PERIODONTITIS.

Aim: The present study evaluates the clinical and immunological efficacy of 0.3% of Triclosan gel as a topical drug application system for the treatment of chronic periodontitis patients in terms of plaque index, gingival index, probing depth, clinical attachment levels (clinical parameters) & level of cytokine IL-1 ?using ELISA. Materials & Methods: A total of 30 patients suffering with chronic periodontitis (20-50 years) were selected & randomly divided equally into two groups to be treated with scaling and root planing (SRP) + 0.3% Triclosan gel (test group) & SRP (Control group) alone. The clinical parameters were assessed at baseline & 30 days, along with the immunological parameters at baseline and 30 days post treatment. Results: Statistically significant reduction in plaque was achieved for both the groups while reduction in gingival index was statistically significant in test group only. When compared to baseline mean pocket probing depth was found to be significantly reduced in test group in comparison to control group. Clinical attachment levels showed statistically significant reduction in both the groups from baseline to 30 days and no significant difference were present in both the groups. Further Test Group demonstrated a statistically significant reduction in level of cytokine IL-1? as compared to Control group from baseline to 30 days. Conclusion: This study, thus demonstrated that 0.3% Triclosan gel can be effectively used as a topical drug delivery system as an adjunct to scaling and root planing for the treatment of in chronic periodontitis patients.