RELATIONSHIP OF SERUM URIC ACID LEVELS AND ANGIOGRAPHIC SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH ACUTE CORONARY SYNDROME USING SYNTAX SCORE.

Background:- The relationship between elevated uric acid (UA) levels and the risk of major forms of atherosclerotic cardiovascular disease has been well demonstrated especially with chronic stable coronary artery disease, but still showing some debate in patients with acute coronary syndrome. Aim:- This study was designed to detect the relationship between serum UA and the severity of coronary artery disease (CAD) in patients with acute coronary syndrome (ACS) as assessed by SYNTAX score. Materials and Methods:- The study was carried on 80 patients who were admitted by ACS and underwent coronary angiography. All patients were assessed for the presence of cardiovascular risk factors .UA levels and other biochemical assessments were measured in all patients after 12 hour fasting before the procedure. The severity of CAD was assessed by the SYNTAX score. The relationship between the serum UA and the severity of CAD was statistically evaluated using IBM SPSS Statistics 21 for Windows. Results:- This study was carried on 80 subjects, 70 of them were males (87.5%) and 10 subjects (12.5%) were females. The mean age in males was (53.6±11.2) years and it was (62.5±8.8) years in females. Among the studied population there were 57 (71.25%) current smokers, 8 (10%) ex-smokers and (18.75%) nonsmokers. Forty-nine patients (81.25%) had hypertension on medical treatment while 35 patients (43.75 %) were diabetic (type 2 DM). the HbA1c was (8.16±2.41) in females and (7.43±1.97) in males. Forty six patients (75.5%) had a history of abnormal lipid profile on medical treatment. The level of uric acid was (5.45±2.45 mg/dl) in females and (5.33±1.61mg/dl) in males Conclusion:- The level of serum uric acid showed no correlation with the calculated SYNTAX score among the studied population (p value = 0.198)