THE RELATION BETWEEN 25 HYDROXYVITAMIN D AND MMP9 PLASMA LEVEL AS SUGGESTED MECHANISM OF CARDIOVASCULAR DISEASES IN HEMODIALYSIS PATIENTS.

Background:- 25-hydroxyvitamin D [25(OH)D] concentration is inversely associated with cardiovascular disorders including coronary arterial disease and hypertension. Vascular remodeling may play a role in this association, however, few data relating vitamin Dlevel to specific remodeling biomarkers among ESRD patients is available. We investigated whether 25(OH)D levelis related to markers of vascular remodeling in ESRD patients. Subjects & Methods:- It included a total number of 65 subjects. They were divided into three groups: Group 1 (29 subjects with severe vitamin D deficiency on regular hemodialysis), Group 2 (14 subjects with moderate vitamin D deficiency on regular hemodialysis) and Group 3 (22 subjects with normal vitamin D level on regular hemodialysis). All patients included in this study were subjected to the following: Full clinical assessment, Complete blood picture, alanine aminotransferase, aspartate aminotransferase, serum albumin, creatinine, blood urea, fasting plasma glucose, serum calcium, serum phosphorus, serum parathyroid hormone, lipid profile, 25 hydroxyvitamin D and MMP9 levels. Results:- Among 65 patients, mean?standard deviation 25(OH)D concentration was 25.27?18.08, and was low(<20ng/ml) in 44.6% of patients. 25(OH) D concentration was inversely correlated withMMP-9 concentration (r = -0.607, p <0.001). In multivariate analysis, MMP-9 concentration remained negativelyassociated with 25(OH) D concentration (P = 0.001). Conclusion:- We detected thatplasma MMP-9 and circulating 25(OH) D concentrations are significantly and inversely associatedamong ESRD patients on hemodialysis. This finding may suggest a potential mechanism by which low circulating 25(OH) Dfunctions as a cardiovascular risk factor.