OBSTATIN AND NUTRITION DISORDERS INEGYPTIAN OBESE WOMEN WITH AUTOIMMUNE THYROID DISEASES.

Background:-Obesity is a major global health problem. Obesity and iron deficiency are two of the most common nutritional disorders worldwide.Iron deficienciescan be the cause of thyroid disorders. Obstatinis an important appetite and energyregulating peptide, secreted by the stomach. This gut peptide and thyroid hormones are involved in nutrition regulation. Few studies have been reported variations of gut hormones in thyroid dysfunction.We aimed to evaluate the possible relationships between serum obstatin, nutrition disorders, and thyroid dysfunction in thyroid peroxidase antibody positive obesewomen. Methods:- case?control study included 150Egyptian patients with autoimmune thyroid diseasesand 50women as controls .Complete blood count, iron, total iron binding capacity, ferritin, thyroid stimulating hormone (TSH), free thyroid hormones (FT4 and FT3), anti-thyroglobulin (anti-TG) ,anti-thyroid peroxidase (anti-TPO) andobstatinwere measured .Fat mass (FM) and fat free mass (FFM) were evaluated by DEXA. Results:-Serum obstatinwere statistically higher in hyperthyroidism patients than in euthyroid cases. However, the serum obstatinlevels were statistically lower in hypothyroidism patients than in those euthyroid. In autoimmune thyroiditis patients, serum obstatin level was positively correlated with hemoglobin, hematocrit, ferritin,serum iron, transferrin saturationratio (TSF), anti TPO, anti TG, TSH, FT3, and FT4. On the contrary, there were significant negative correlations between serum obstatin level and indices of obesity; mid arm circumferences (MAC).body mass index (BMI), FM, FFM and FFM.In autoimmune thyroiditis patients, linear regression analysis showed thatserumobstatin levels were independently correlated with hemoglobin,hematocrit and serum iron levels, Conclusion:- In this study,serum obstatinwere higher in hyperthyroidism patients and lower in hypothyroidism patients than in euthyroid.Moreover obestatn, iron deficiency parameters (hemoglobin, hematocrit serum iron, ferritin, TFS and TIBC) and body composition parameters(FM, FMI, FFM and FFMI)associated with different types of thyroid dysfunction.Our results suggested thatthe gut peptide, obstatin can be a valuable diagnostic marker of nutrition disorders especiallyin obeseautoimmune thyroiditis patients.