30Mar 2016

ASSOCIATION OF SERUM LEPTIN WITH INFLAMMATION, ANEMIA AND BODY MASS INDEX IN EGYPTIAN CHRONIC HEMODIALYSIS PATIENTS.

  • Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Abstract
  • Keywords
  • Cite This Article as
  • Corresponding Author

Background:- ESRD is a major healthcare problem worldwide, especially in developing countries. Nutrition disorders especial anemia and loss of weight are very common and important risk factors for morbidity and mortality in patients on regular hemodialysis and so We aimed to evaluate the relationship between serum leptin,anemia and nutrition state in patients on regular hemodialysis Subjects and methods:- A case- control study included 55 Egyptian patients on chronic hemodialysis 34 healthy subjects as control. Each group were stratified according to their body mass index (BMI) to four subgroup, In all studied participants we determined BMI, body surface area (BSA) and waist to hip ratio (WHR), blood urea, serum creatinine, sodium, potassium , calcium, phosphorus , albumin, serum bilirubin. ALT, AST, complete blood count, Lipid profile, HbA1c, fasting blood glucose (FBG), post prandial blood glucose were measured.Also,we estimate serum leptin andCRP levels. Results:- there were highly statistical significance differences between cases and control in Leptin and CRP with marked elevated level in hemodialysis group(HD)compared to control group.There was positive correlation between BMI and leptin in cases group with marked elevated level in obese and over- weight compared to under -weight and normal cases but there was no significant correlation in control group. In hemodialysis group,there was non- significant correlation between CRP and leptin level.Linear regression analysis showed that, serum leptin levels were independently correlated with diastolic blood pressure and platelet in hemodialysis group. Conclusion:- In the present study, serum leptin and CRP levels were higher in Egyptian patients. On regular hemodialysis, there were significant positive correlation between serum leptin levels and BMI. According to the results of this study, serum leptin can be used as diagnostic marker of nutrition disorders especially anemia and weigh changes in patients with ESRD on hemodialysis

[Nabila A. Hussien, Nearmeen M. Rashad, Amira A. Mahmoud, Myada M. Mousa, Marwa A Aly and Nermin Raafat. (2016); ASSOCIATION OF SERUM LEPTIN WITH INFLAMMATION, ANEMIA AND BODY MASS INDEX IN EGYPTIAN CHRONIC HEMODIALYSIS PATIENTS. Int. J. of Adv. Res. 4 (Mar). 1316-1328] (ISSN 2320-5407). www.journalijar.com

Nearmeen M. Rashad

Download Full Paper

Download PDF No. of Downloads: 14 | No. of Views: 83