EFFECT OF EXTRACTED ALOE VERA IN COMPARISON WITH MARKETED PREPARATION ON ALLOXAN INDUCED DIABETIC FOOT ULCERS PRODUCED BEHAVIOURAL DYSFUNCTIONS BY USING RODENTS.

The core finding of the present preclinical study demonstrated that, administration of prescribed oral and topical doses of Aloe Vera is remarkably protective effects in diabetic and its complication using male wistar rats against alloxan induced Diabetic Foot Ulcers (DFU). Diabetes mellitus is an endocrine disorder. Diabetes mellitus is now defined as a metabolic disorder in which the body?s capacity to utilize glucose, fat and protein is disturbed due to insulin deficiency, insulin resistance or both. Diabetes mellitus is a condition which is known to be associated with a variety of connective tissue abnormalities such as DFU.The collagen content of the skin is decreased as a result of reduced biosynthesis and or accelerated degradation of newly synthesized collagen. These qualitative and quantitative abnormalities contribute to the impaired wound healing observed in diabetes.Aqueous extract of Aloe Vera (AGE, Oral) with ethanol extract of Aloe Vera (AG, Topical) act as diabetes and its complication such as DFU protective agent. Relevant doses of Aloe Vera treatment (Extracted& Marketed products) protects behavioral changes, significantly attenuated oxidative damage & improved anxiety and depression activities in different regions of central nervous system (CNS) of rat brain against alloxan induced connective tissue abnormality in diabetic wound. Subcutaneous administration of alloxan is known to produce insulin deficiency that resembles juvenile onset and advanced diabetic disease in rats. The results show that Aloe Vera treatment is effective in various DFU produced behavioral dysfunction; it could be used as an effective therapeutic agent in the management of Diabetic foot ulcers and related conditions comparison with marketed products containing Aloe Vera.