STUDY OF MAGNESIUM LEVEL IN POLYCYSTIC OVARIAN SYNDROME

Background: Polycystic Ovarian Syndrome, characterized by hyperandrogenism, oligomenorrhoea / anovulation and polycystic ovaries is the most common endocrine disorder in females of reproductive age group and are found to have an increased incidence of insulin resistance. As magnesium plays the role of a second messenger for the action of insulin, this study aims to investigate the level of serum magnesium in patients with polycystic ovarian syndrome. Aim: To evaluate the level of serum magnesium in infertile women with polycystic ovarian syndrome and to study its possible association with insulin resistance. Materials and methods: After getting Ethical Committee approval, informed, written consent were obtained from 30 infertile PCOS women aged 25 - 35 years (study group) and 30 age matched parous women (control group), history, general, systemic and laboratory examinations - fasting plasma glucose by Glucose Oxidase Peroxidase Method and serum magnesium by spectrophotometric method were carried out. Result: Statistical analysis was done by student- t test and the results were compared between study group and control group.There was a significant increase in fasting plasma glucose levels (p <0.001) with decrease in serum magnesium levels (p< 0.001) in patients with PCOS as compared to controls. Conclusion: This study confirms the association between serum magnesium and glucose levels in PCOS. Since women with PCOS are at a risk of developing Type 2 Diabetes Mellitus screening for magnesium is necessary in these patients.