Serum level of Leptin and Ghrelin in Juvenile Rheumatoid Arthritis and their correlation to disease activity and body mass index
- Departments of Physical medicine and rehabilitation , Faculty of Medicine, Tanta University, Egypt.
- Physiology , Faculty of Medicine, Tanta University, Egypt.
- Department of laboratory medicine Faculty of public Health, Benghazi University, Lybia.
- Department of Nutrition Faculty of public Health, Benghazi University, Lybia.
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Aim of the work: This study was designed to investigate the serum level of Leptin and Ghrelin in Juvenile Rheumatoid Arthritis (JRA) and its correlation to disease activity and body mass index (BMI) Patients and methods: This study included sixty JRA patients (38 females and 22 males) and forty matched healthy controls (26 females and 14 males). levels of ghrelin and leptin were measured by ELISA and correlate these levels with Juvenile Arthritis Disease Activity Score (JADAS) and patients BMI. Complete blood count (CBC), Erythrocyte sedimentation rate (ESR) mm/1st h, Serum C- reactive protein (CRP) and interleukin 6 were measured. Results: Significant increase of serum level of Leptin and IL-6 and significant decrease of serum level of ghrelin in patients group as compared with control group. Significant increase in serum level of leptin in active group as compared with inactive group, while there was no significant change in serum level of ghrelin in active as compared with inactive patients. Significant positive correlations were found between ghrelin and leptin serum levels and patients’ BMI. Conclusion: leptin and Ghrelin may be responsible for weight loss in JIA, and may have a role in the pathogenesis of the disease.
[Manal Shawky Hussein, Elsayed Emara, Ahmida Mohamed (2015); Serum level of Leptin and Ghrelin in Juvenile Rheumatoid Arthritis and their correlation to disease activity and body mass index Int. J. of Adv. Res. 3 (Oct). 916-921] (ISSN 2320-5407). www.journalijar.com
