Effect of Magnesium Sulphate on postoperative pain in laparoscopic cholecystectomy

Background: Adequate post operative pain relief contributes significantly to patient comfort and a good post operative recovery. Magnesium sulphate has been recently shown to have a potential to prevent post operative pain. The present study was designed primarily to study the effect of Magnesium Sulphate on analgesic requirement of patients undergoing laparoscopic cholecystectomy. Aim: To evaluate the efficacy of administration of magnesium sulphate to produce adequate post operative pain relief after laparoscopic surgery. Methods: After taking informed consent, 60 patients were systematically randomised into two groups of 30 each. Patients were kept NPO 8 hours prior and given Tablet Alprazolam 0.25mg and Omeprazole 20 mg at bed time day before surgery and morning of surgery.Group1 received Magnesium sulphate 50 mg/kg in 250 ml of isotonic 0.9%N.S intravenously over 15 to 20 minutes in the preoperative room and Group II ,Same volume of isotonic 0.9%N.S iv. over 15 to 20 minutes ,before shifting the patient immediately afterwards to the operation room. Results: Magnesium sulphate pretreatment in a dose of 50 mg/kg body weight intravenously before laryngoscopy and intubation effectively reduces and delays post-operative analgesic requirement by reducing post-operative pain. Conclusion: Magnesium sulphate produce adequate postoperative pain relief associated with laparoscopic cholecystectomy.