Hematotoxicity induced by sub-chronic dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Swiss albino mice (Mus musculus)
- Department of Botany, Thakur Prasad Smriti College, Magadh University, Patna.
- Department. Of Botany, B.M.D College, Dayalpur, B.R.A Bihar University, Bihar, India.
- Research Centre, Mahavir Cancer Sansthan, Phulwarisharif, Patna, India.
- S.S. Hospital and Research Institute, Patna, India.
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Present study was designed to determine the acute oral toxicity (LD50) and investigate the effect of sub-chronic dose (0.5µg/Kg body wt.) of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on the haematological parameters in Swiss albino mice. The LD50 was found 5.087 ?g/Kg body wt. in Swiss albino mice. The effect of sub-chronic dose of TCDD on the haematological parameters showed statistically very significant (P<0.01) decrease in the levels of RBC (red blood cell), Hb (Haemoglobin), MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Haemoglobin), MCHC (Mean Corpuscular Haemoglobin Concentration), and HCT (Hematocrit). Whereas, statistically significant (P<0.05) increase in the level of WBC (White blood cell) was observed as compared to control group. The research finding suggests that exposure of sub-chronic dose of TCDD significantly altered the haematological parameters, which is relevant to risk evaluation of TCDD that may be used as a predictive values for its toxicity in mammalian system including human being.
[Tanuja, Ruchi, Anjali Singh and J.K. Singh (2015); Hematotoxicity induced by sub-chronic dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Swiss albino mice (Mus musculus) Int. J. of Adv. Res. 3 (Sep). 1318-1322] (ISSN 2320-5407). www.journalijar.com
