Effects of Atorvastatin against Cisplatin Induced Nephrotoxicity in Rabbits
- Department of Pharmacology, College of Medicine, AL-Nahrain University, Baghdad, Iraq.
- Department of Pathology, College of Medicine, AL-Nahrain University, Baghdad, Iraq.
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Nephroprotective effect of atorvastatin was investigated in rabbits with acute renal injury induced by a single i.p. injection of cisplatin (6.5 mg/kg). Atorvastatin treatment (10 mg/kg/day, orally) was applied for 7 consecutive days, starting 4 days before cisplatin administration. Atorvastatin significantly reduced serum creatinine levels and increased serum albumin levels which were altered by cisplatin. Atorvastatin significantly compensated deficits in kidney tissue glutathione level,suppressed lipid peroxidation, and decreased the elevations of serum tumor necrosis factor-alpha resulted from cisplatin administration. Also, histopathological renal tissue damage mediated by cisplatin was mildly ameliorated by atorvastatin treatment. Atorvastatin showed no significant effect on serum urea, or inflammatory cell infiltration. It was concluded that atorvastatin represents a potential therapeutic option to protect again
[Ali H. Abady, Ahmed R. Abu-Raghif, Ban J Qasim (2015); Effects of Atorvastatin against Cisplatin Induced Nephrotoxicity in Rabbits Int. J. of Adv. Res. 3 (Oct). 879-885] (ISSN 2320-5407). www.journalijar.com
