Histological and biochemical alteration from in ovo exposure to Aflatoxin B1
- Division of Toxicology, Department of Zoology, Faculty of Science, The M.S. University of Baroda, Vadodara, Gujarat 390002, India.
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Aflatoxin B1 (AFB1) is one of the most hazardous toxins that are produced by many species of Aspergillus as secondary metabolic products. The present study assessed the effects of in ovo exposure of AFB1to RIR eggs. The various biochemical parameters and histopathological changes were noted at the end of incubation. Changes in biochemical parameters were more intense in AFB1 treated hatchling. The levels of ALT, AST and total protein were significantly elevated in AFB1 exposed group when compared to the control. In ovo AFB1 treatment was resulted into significantly decrease level of glucose in serum. The activity of stress marker enzyme like SOD, glutathione peroxidase and reduced glutathione level decreased while the level of lipid peroxidation increased due to AFB1 intoxication. Significant histopathological changes such as hepatic degeneration, loss of hepatocytes arrangement and vacuolization has been found in the liver tissue of treated hatchling. In conclusion, the results of this study demonstrate that in ovo exposure of aflatoxin altered biochemical parameters and stress marker enzyme which has correlation with histopathological changes of liver tissue. Key words: Aflatoxin B1, in ovo, Hepatotoxicity, biochemical parameters, Histopathology
[Manjurmahammad D. and Suresh B., Hetal R. (2015); Histological and biochemical alteration from in ovo exposure to Aflatoxin B1 Int. J. of Adv. Res. 3 (Aug). 1223-1229] (ISSN 2320-5407). www.journalijar.com
