CLINICOPATHOLOGICAL STUDY OF BONE LESIONS IN TERTIARY CARE CENTER – A REVIEW OF 80 CASES

Introduction: Bone tumours are comparatively uncommon among wide array of lesions and pose a diagnostic problem as they constitute a small portion of diagnostic experience among pathologist. Aims & Objective: To study the histopathological features of bone lesions and their correlation with age of presentation, site and type of lesion. Material and Methods: The present study was carried out at a tertiary care center from June 2013 to May 2015. A total of 80 bone lesions were analyzed. A detail clinical and radiological history was taken. Bone biopsy was performed by either percutaneous method with needle/drill or Open surgical biopsy. If attached soft tissue was also received, bony tissues were put for decalcification (10% nitric acid) and soft tissue was immediately fixed into 10 % formalin and processed by paraffin embedding. Sections were stained by haematoxylin and eosin stain. Results: Incidence of non-neoplatic and benign neoplastic lesions was (68.75%) while that of malignant lesion was only 20 %.Younger patients (58.24%) and males (60%) were more commonly affected. Amongst non-neoplastic lesions, tuberculous lesions (17.5%) were commonest while exostosis (osteochondroma) (15%) was common benign and osteosarcoma and chondrosarcoma were common malignant neoplastic lesions. Overall most common bone involved was femur. Osteolytic lesions were more common. Metaphysis was the commonest site. In tuberculous lesions, vertebrae were commonly involved. Conclusion: Though bone tumours are less common lesions and pose a diagnostic problem, if viewed in perspective of clinico-radiology and histopathology, a correct diagnosis can be reached.