IMPACT OF MICELLAR CHARACTERISTICS ON THE DISSOLUTION AND EFFICACY OF ANTICANCER AGENTS: A REVIEW

Micellar drug delivery system is one of the potentially efficient approaches for increasing the solubility, stability, and bioavailability of hydrophobic anticancer agents. This review study investigates the effects of major micellar properties on the solubility and therapeutic effectiveness of anticancer medications, including size, shape, surface charge, and stability. The non-spherical micelles may increase cellular uptake and lengthen circulation time, while smaller micelles may improve drug solubility and tumor penetration as various studies suggest. The surface charge of particles is also a critical factor in determining how they interact with cells.Stable micelles improve therapeutic results by delaying the onset of drug release. Furthermore, controlled release of encapsulated medications is possible with micelles, enhancing targeted delivery to tumor sites. Notwithstanding the advantages, problems like long-term stability and early medication release still exist. The results of this review study highlight the possibility of enhancing micellar properties to raise the effectiveness of anticancer treatments, opening the door to more potent and focused cancer therapies.