EFFICACY AND SAFETY OF MIRABEGRON PLUS VITAMIN D3 VS MIRABEGRON ALONE IN THE TREATMENT OF ADULT PATIENTS OF OVERACTIVE BLADDER: A RANDOMIZED CONTROLLED TRIAL

Introduction: Overactive bladder (OAB) is a syndrome of complex etiology affecting millions of patients worldwide. Both pharmacological and non-pharmacological treatment options have been tried for resolution of its symptoms with limited option in pharmacotherapy of OAB. β₃ receptor agonists like mirabegron are now mainstay of treatment.

Material and methods: This open labelled, randomized controlled study was conducted with 99 patients divided into 3 groups based on their vitamin D levels and evaluation of OAB symptoms was done at baseline, 4 weeks, 8 weeks and 12 weeks using urgency severity score (USS), overactive bladder symptoms severity score (OABSS) and three days voiding diary.

Result: At each follow-up visit severity of symptoms reduced gradually and difference was statistically significant in all the parameters. There was significant difference between group B and group C at the end of study. 

Conclusion: This study concluded that severity of the symptoms was higher in Vitamin D insufficient patients and reduction in symptoms was higher in group C suggesting that vitamin D supplementation may be helpful in reducing the symptoms of OAB.