ORGANOTIN BIS-COMPLEXES: Synthesis, Characterization, antimicrobial activity and Anticancer (computational) studies
- Faculty ,Zlife education.
- Assistant Professor, Department of Applied Chemistry, Amity University, Noida (India).
- Associate Professor, Department of Chemistry,ARSD College, Delhi University, New Delhi-110021.
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The synthesis of new Organotin (IV) based complexes were reported as well as charecterization by several spectrocopic techniques. The stannanes were successfully synthesized in high yield and based on the ligands, tin complexes were prepared and characterized. A possible structure of novel complexes has been proposed as evident from spectral studies. The complexes were tested against subsequent bacterial strains Staphylococus aureus (gram positive) and Escherichia coli 1610(gram negative) and their antifungal activity was evaluated against two fungal strains of Fusarium and Aspergillus niger. Synthesized organotin (IV) complexes had revealed good antibacterial and antifungal activities. Further, computational study of synthesized stannanes was performed using iGEMDOCK software. In which complex A was found to inhibit the B-RAF Kinase activity and therefore it could be a potential pharmaceutical drug which can be advantageous for melanoma patients.
[Rohit Babu Aniyery, Anita Gupta, Prashant Singh (2015); ORGANOTIN BIS-COMPLEXES: Synthesis, Characterization, antimicrobial activity and Anticancer (computational) studies Int. J. of Adv. Res. 3 (Jul). 262-273] (ISSN 2320-5407). www.journalijar.com
