Genetic Instabilities and Oxidative Stress in Congenital TORCH Infected Children
- Department of Medical Microbiology, Sree Gokulam Medical College, Thiruvananthapuram- 695607.
- Department of Medical Biochemistry, Sree Gokulam Medical College, Thiruvananthapuram- 695607.
- School of Health Sciences, Kannur University- 670661.
- Department of Microbiology, St. Pius X College, Kasargod- 671532.
- Genetika, Centre for Advanced Genetic Studies, Pettah P O, Thiruvananthapuram-695 024, India.
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The maternal infections that are transmissible in utero at several stages of the pregnancy can be caused by a group of infectious organisms, namely TORCH. These are associated with multiple abortions, sterility, intrauterine foetal death or malformations because of the foetus’s inability to resist infectious organisms and the DNA damages caused by them. The oxidative stress plays a role in the pathophysiology of these abnormalities. The aim of the present study was to evaluate the role of oxidative stress and DNA damages in congenitally TORCH infected children. The study measured the level of oxidative stress by Malondialdehyde (MDA) test and the DNA damages are quantified by CBMN assay. Detailed demographic, lifestyle and clinical characteristics were compared with the results obtained. The mean CBMN frequencies as well as MDA values are observed to be higher in 47 congenitally TORCH infected children than the 16 control children. The present study observed a positive correlation between congenital TORCH infection and the oxidative DNA damage and thereby measures the effect of teratogens in pregnant women. This aids to aware the people about the cytogenetic effects of the environmental factors.
[Swapna C Senan, Aswathy Sundaresh, Jisha P., Sarala Gopalakrishnan, Anjali K., Dinesh Roy D. (2015); Genetic Instabilities and Oxidative Stress in Congenital TORCH Infected Children Int. J. of Adv. Res. 3 (Jun). 984-989] (ISSN 2320-5407). www.journalijar.com
