Designed Synthesis and bio evaluation of 2, 3-disubstituted quinazolin- 4-(3H)-ones promoted camphor sulfonic acid as a catalyst

A straightforward, practical, and economical process for producing quinazolin- 4-(3H)-ones derivatives is describe and a series of derivatives of the 2, 3-di-substituted quinazolin-4-(3H)-ones have been synthesized as a one pot synthesis of the reaction of 2-amino-N-phenyl benzamine and various substituted aromatic aldehyde in the presence of camphor sulfonic acid catalyst in a ethanol as solvent. The final derivatives can be characterized by 1HNMR, 13CNMR & Mass and besides the derivatives examined biological activity. No toxic organic solvents are used in the current procedure. Shortest reaction time, high product yields, easy work-up process, and non-chromatographic product purification are only a few of this catalyst's encouraging reaction response characteristics.