Cytotoxic effect of biosurfactants produced by novel thermophillic Geobacillus thermoleovorans (JQ 912239).
- Dept. of Molecular & Medical Biotechnology, College of Biotechnology, Alnahrain University, Baghdad, Iraq.
- Dept. of Biotechnology, College of Science, Alnahrain University, Baghdad, Iraq.
- Dept. of Biotechnology, College of Science, Baghdad University, Baghdad, Iraq.
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In recent years, interest has been growing in the cytotoxic effect of biosurfactant. The aim of this study was to investigate the cytotoxic effect of biosurfactant on breast cancer (MCF7) cell line. Geobacillus thermoleovorans (JQ 912239) gave good result for biosurfactant production with emulsification index and surface tension reduction. MCF7 cell line was exposed to different concentration of biosurfactant and apoptotic death was assessed by monitoring cell accompanied by caused a significant decrease of cell count, with significant increase in cell permeability, cytochrome C releasing from mitochondria, and nucleus intensity and a significant reduction in mitochondrial membrane potential of MCF7 cells.
[Majid H. AL-Jailawi, Hiba M. Nasir, Ghazi M. Aziz (2015); Cytotoxic effect of biosurfactants produced by novel thermophillic Geobacillus thermoleovorans (JQ 912239). Int. J. of Adv. Res. 3 (Jun). 632-637] (ISSN 2320-5407). www.journalijar.com
