STREAMLINED SYNTHESIS: ENHANCING THE LEIMGRUBER-BATCHO INDOLE ROUTE FOR ONE-POT TANDEM PRODUCTION OF 2,3-UNSUBSTITUTED INDOLES
- General Manager, Chemical Research and Development, Sunlight Active Drug Intermediates, ALEAP, Pragathi Nagar, Hyderabad, Telangana State, India-500090.
- Managing Director, Chemical Research and Development, Sunlight Active Drug Intermediates, ALEAP, Pragathi Nagar, Hyderabad, Telangana State, India-500090.
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Aim:This study aims to create a new one-pot synthesis method for substituted indoles, focusing on efficiency, by-product reduction, and comparative advantages over conventional Leimgruber-Batcho reactions.
Methods:Researchers optimized a one-pot synthesis strategy for maximum yield, reduced by-products, and resource utilization, comparing it to traditional Leimgruber-Batcho reactions, ensuring a sustainable, environmentally friendly approach.
Results:The one-pot synthesis method efficiently produced substituted indoles with reduced environmental impact, yielding more than conventional reactions, shortened reaction times, and aligning with green chemistry principles.
Conclusions:The one-pot synthesis method for substituted indoles, using 2-nitrotoluenes and dimethylformamide dimethyl acetal, is a significant advancement in the field, offering improved efficiency, environmental sustainability, and higher yields compared to conventional methods, making it a more resource-effective and economically viable option.
[Aviraboina Siva Prasad and Talupula Venkateswara Rao (2024); STREAMLINED SYNTHESIS: ENHANCING THE LEIMGRUBER-BATCHO INDOLE ROUTE FOR ONE-POT TANDEM PRODUCTION OF 2,3-UNSUBSTITUTED INDOLES Int. J. of Adv. Res. (Feb). 528-532] (ISSN 2320-5407). www.journalijar.com
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