Spectrum of Chromosomal Abnormality among 84 Indian Infertile Couples

The aim of this study was to investigate the contribution of chromosomal anomalies and the frequency of particular types of aberrations in general couples preparing for pregnancy and make recommendations for pregnancy on the basis of the medical literature. A total of 84 general couples were included in the present study. The karyotypes were generated from the peripheral blood lymphocyte cultures and the cytogenetic analysis was performed using G-banding. In 84 couples, chromosomal anomalies were detected in 26 cases (30.95%, 26/84). Among them, the frequency of translocation was 4.76% (n=4), deletion was 5.95% (n=5) and autosomal derivatives was 1.19% (n=1). Sex chromosomal numerical anomalies accounted for 19.04% (n=16), including Klinefelter syndrome (KS) (n=3), Turner syndrome (TS) (n=3), and XYY syndrome (n=1). The others, including presence of mosaic cell lines was accounted for 10.71% (n=9).Our study indicates that clinically important chromosomal defects are present at a remarkable frequency in the general couples of eastern India, suggesting pre-pregnancy cytogenetic analysis should be routinely performed among general couples of this area, so that informed decision can be made, which will help to improve the quality of the pregnancy.