Estimation of level of MDA and SOD in oral cancer patients and their suppression by antioxidants.

In the last decade there has been a rapid progress in the understanding of the actual nature and chemistry of reactive oxygen species (ROS) at the cellular and molecular level. Free radicals have been implicated to play a pivotal role in genesis of various oral cancers. All the major classes of biomolecules may be attacked by free radicals but lipids are most susceptible. Celll membranes are rich source of polyunsaturated fatty acid (PUFAs) which are readily attacked by Oxidized radicals. The free radicals cause oxidative destruction of polyunsaturated fatty acids Known as lipid peroxidation. It is particularly damaging because it proceeds as self perpetuating chain reaction, which may result in more free radical generation. Free radicals are indirectly measured by the level of MDA (malony dialdehyde). Keeping in view such consideration, this study has been designed to the role and activities of ROS and some significant stress markers such as MDA and SOD/ Catalase as enzymatic, antioxidants in oral cancer patients