Relationship between Hyperuricemia and Vitamin D Deficiency among Adult in Al Kharj, Saudi Arabia.

Background Relationship between hyperuricemia and vitamin D deficiency in Saudi Arabia has not been reported so far, although hyperuricemia and vitamin D deficiency are common. We aimed to study the relationship of elevated serum uric acid with vitamin D deficiency among adult in Al Kharj. Subjects and Methods We collected data from 181 participants attending Salman Bin Abdul Aziz University Hospital, Al Kharj from September to December 2014. Serum uric acid, 25-hydroxy vitamin D and other traditional biomarkers including fasting plasma glucose, blood lipids, were assessed in 131 patients aged above 18 years. In addition to 50 patients (volunteer) with normal uric acid level as control.Relationship between serum uric acid and vitamin D level was analyzed. Results The mean age of the studied patients was 37.42± 12.853. Obesity and vitamin D deficiency were prevalent in patients with elevated SUA (Hyperuricemic) as they were reported in 71.8% , 63.4% respectively. More than half of the hyperuricemic patients had increase level of glucose (60%) and abnormal cholesterol level mainly for LDLcholesterol as 77.9% had higher level. Hyperuricemic patients with vitamin D deficiency had higher levels of TG, TC and LDL cholesterol and lower level of HDLcholesterol than those with normal SUA level, but this difference was significant only for LDL cholesterol. SUA was inversely correlated with vitamin level and significantly correlated with LDLcholesterol . Conclusions Obesity , vitamin D deficiency and high LDL cholesterol level were prevalent in hyperuricemic patients and elevated uric acid was correlated with LDL cholesterol and vitamin D deficiency.. Recommendation Further clinical trial are needed to confirm the relation of hyperuricemia with vitamin D deficiency and to clarify the impact of vitamin D supplementation on hyperuricemia and consequently the influence of SUA lowering treatment on CVD prevention.