CORRELATION BETWEEN HEMOGLOBIN A1C AND SERUM LIPID PROFILE WITH TYPE 2 DIABETES: A CROSS-SECTIONAL STUDY

Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Patients with type 2 diabetes (T2DM) have an increased prevalence ofdyslipidemia, which contributes to their high risk of cardiovascular diseases (CVDs). This study is an attempt to determine the correlation between hemoglobin A1C (HbA1c) and serum lipid profile and to evaluate the importance of HbA1c as an indicator of dyslipidemia with Type II diabetes mellitus.

Methods: The study had 240 participants between the age groups of 20-70 years included 80 males and 40 females in diabetic group whereas the control group included 78 males and 42 females. T.cholesterol, Triglycerides, HDL were calculated by semi automated analyzer and LDL and VLDL were calculated by Friedewald’s Formula. HbA1c was measured by turbidMetric Method.

Results: Data was represented as mean ± standard deviation or median with statistically significant values of T. Cholesterol, LDL, HDL, TGs and HbA1c (P< 0.001). There was a significant positive correlation between HbA1c, TC, TG, and LDL-C. Patients with HbA1c value greater than 7.0% had significantly higher value of cholesterol, LDL-C, and compared with patients with an HbA1c value up to 7.0%.

Conclusion: Significant positive correlation of HbA1c with Lipid profiles in our study suggests that HbA1c can also be used as a predictor of dyslipidemia in addition to a glycemic control parameter for prevention of complication.