12May 2020

EXOPHTALMOS REVEALING A CARCINOID HEART DISEASE: A CASE REPORT

  • Cardiology Department, Hospital Center of Perpignan, France.
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Carcinoid heart disease is rare, and it is one of the primary pathologies of tricuspid and pulmonary valve. We present a 42-year-old woman who presented to our cardiology clinic with recent peripheral lower limb edema and dyspnea. Cardiac auscultation revealed a tricuspid regurgitation murmur the reason why we did the transthoracic echocardiography that demonstrated a unique right sided valvular heart disease with a morphological aspect of carcinoid heart disease. The patient has a right exophthalmos in the clinical examination that was highly suggestive of a brain tumor. So we decided to admit her in the hospital for further work up.

  1. Miller JK: Carcinoid syndrome and the APUD concept. Semin Anesth 1987; 3:228?37.
  2. Pellikka PA, Tajik AJ, Khandheria BK, et al. Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients. Circulation 1993;87(4):1188?96.
  3. Lundin L, Norheim I, Landelius J, et al. Carcinoid heart disease: relationship of circulating vasoactive substances to ultrasound-detectable cardiac abnormalities. Circulation 1988; 77(2):264?9.
  4. Connolly HM, Nishimura RA, Smith HC, et al. Outcome of cardiac surgery for carcinoid heart disease. J Am Coll Cardiol 1995; 25(2):410?6.
  5. Pandya UH, Pellikka PA, Enriquez-Sarano M, et al. Metastatic carcinoid tumor to the heart: echocardiographic-pathologic study of 11 patients. J Am Coll Cardiol 2002; 40:1328.
  6. Simula DV, Edwards WD, Tazelaar HD, et al. Surgical pathology of carcinoid heart disease: a study of 139 valves from 75 patients spanning 20 years. Mayo Clin Proc 2002; 77:139.
  7. Bhattacharyya S, Toumpanakis C, Burke M, et al. Features of carcinoid heart disease identified by 2- and 3-dimensional echocardiography and cardiac MRI. Circ Cardiovasc Imaging 2010; 3:103.
  8. Connolly HM, Schaff HV, Mullany CJ, et al. Surgical management of left-sided carcinoid heart disease. Circulation 2001; 104:I36.
  9. Grozinsky-Glasberg S, Grossman AB, Gross DJ. Carcinoid heart disease: from pathophysiology to treatment-?Something in the way it moves?. Neuroendocrinology 2015; 101(4):263?73.
  10. Rajamannan N, Caplice N, Anthikad F, et al. Cell proliferation in carcinoid valve disease: a mechanism for serotonin effects. J Heart Valve Dis 2001; 10(6):827?31.
  11. Roy A, Brand N, Yacoub M. Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves. J Heart Valve Dis 2000;9(2):256?60 [discussion: 260?1].
  12. Walker GA, Masters KS, Shah DN, et al. Valvular myofibroblast activation by transforming growth factor-b. Circ Res 2004; 95(3):253?60.
  13. Bergestuen DS, Edvardsen T, Aakhus S, et al. Activin A in carcinoid heart disease: a possible role in diagnosis and pathogenesis. Neuroendocrinology 2010;92(3):168?77.
  14. David J Fox, Rajdeep S Khattar. Heart 2004; 90:1224?1228. doi: 10.1136/hrt.2004.040329.
  15. Pellikka PA, Tajik AJ, Khandheria BK, et al. Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients. Circulation 1993; 87:1188?97.
  16. Pandya U, Pellikka P, Enriquez-Sarano M, et al. Metastatic carcinoid tumour to the heart: echocardiographic-pathologic study of 11 patients. J Am Coll Cardiol 2002; 40:1328.
  17. Westberg G, Wangberg H, Ahlman C, et al. Prediction of prognosis by echocardiography in patients with midgut carcinoid syndrome. Br J Surg 2001; 88:865?82.
  18. Connolly HM, Schaff HV, Mullany CJ, et al. Surgical management of left sided carcinoid heart disease. Circulation 2001; 104:I36?40.
  19. Heidi M Connolly, Catherine M Otto, Carcinoid heart disease, UpToDate 2018.
  20. Bhattacharyya S, Toumpanakis C, Burke M, et al. Features of carcinoid heart disease identified by two- and three-dimensional echocardiography and cardiac magnetic resonance imaging. Circ Cardiovasc Imaging 2010; 3(1):103?11.
  21. Warrell DA, Cox TM, Firth JD, Benz EJ, eds. Oxford textbook of medicine, 4th Oxford: Oxford University Press, 2003.
  22. Matthew HK, Robert JM. Carcinoid tumours. N Engl J Med 1999; 340:858?68.
  23. Davar J, Connolly HM, Caplin ME, et al. Carcinoid Heart Disease Guidelines. American college of cardiology. 2017.
  24. Robiolio PA, Rigolin VH, Harrison JK. Predictors of outcome of tricuspid valve replacement in carcinoid heart disease. Am J Cardiol 1995;75:485?8.

[Khelifi Lamiae MD, Dinia Mohamed MD and Mandoorah Baraa MD (2020); EXOPHTALMOS REVEALING A CARCINOID HEART DISEASE: A CASE REPORT Int. J. of Adv. Res. 8 (May). 609-615] (ISSN 2320-5407). www.journalijar.com

KHELIFI Lamiae
Hospital center of Perpignan

DOI:

Article DOI: 10.21474/IJAR01/10966      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10966

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