03May 2020

AN ASSESSMENT OF THE INTERACTION BETWEEN INSECT BRAIN PROTEIN AND NON-STRUCTURAL PROTEIN OF CORONAVIRUS USING IN-SILICO ANALYSES

  • Department of Biotechnology, Mithibai College, Vile parle (w), Mumbai-400056.
  • Department of Bioinformatics, Patkar-Varde, Goregaon (w), Mumbai-400104.
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Corona is an avian and mammalian Ribovirus which generally evade host immune mechanism hampering respiratory tract of the host. Structurally it has an envelope of protein enclosing a single-stranded positively coiled RNA genome. Coronavirus uses around 4-5 different classes of protein for its replication in the host cell. Due to the high mutation rate of the viral genome development of a vaccine against corona has been a difficult task. In the current scenario, the world is facing a problem with CoViD-19 as the biggest pandemic. Several combinations of drugs like Hydroxychloroquine, Plaquine, Chloroquine, etc. targeting viral protein have been utilized for controlling viral infection. The possibility of insect brain proteins was checked against the selected non-structural proteins of CoViD-19 that take an active role in the replication of the virus in the host. Molecular docking methodology plays an important role in predicting interaction between the insect proteins with non-structural protein (nsp) of coronavirus. The results predict good bonding affinity with possible interaction as hydrogen bond and salt bridge between antibacterial protein and nsp of CoViD-19 indicating as afuture alternative medications.

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[Siddharth Sagar, Jayaprada Rao Chunduri and Vyomesh Javle (2020); AN ASSESSMENT OF THE INTERACTION BETWEEN INSECT BRAIN PROTEIN AND NON-STRUCTURAL PROTEIN OF CORONAVIRUS USING IN-SILICO ANALYSES Int. J. of Adv. Res. 8 (May). 436-452] (ISSN 2320-5407). www.journalijar.com

Siddharth Sagar
Department of Biotechnology, Mithibai College, Vile parle (w), Mumbai-400056.

DOI:

Article DOI: 10.21474/IJAR01/10945      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10945

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