A STUDY OF ESTIMATION OF TSH,PROLACTIN, FSH AND LH HORMONE LEVELS IN PCOS
- Assistant professor, Department of Biochemistry, Kurnool Medical College, Kurnool, Andhra Pradesh, India
- Professor and Head of Department of Biochemistry, Kurnool Medical College, Kurnool Andhra Pradesh, India
- Abstract
- Keywords
- References
- Cite This Article as
- Corresponding Author
Background:Polycystic ovary syndrome (PCOS) is a common endocrine condition affecting women of reproductive age and characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries. PCOS patients usually develop thyroid disorders which have an adverse effect on fertility and other hormones. Hence this study was done to estimate levels of TSH , LH, FSH, and Prolactin. Aims &Objectives: To study levels of TSH , LH, FSH, and Prolactin and to compare it with healthy matched controls Materials & Methods: The study was conducted in Department of Biochemistry ,Kurnool Medical College and Department of Obstetrics & Gynaecology , Government General Hospital , Kurnool Results:The PCOS group exhibited significantly higher mean thyroidstimulating hormone level , luteinizing hormone level.The study showed that LH is raised in PCOS with p value of 0.0001 which is statistically significant. The ratio of LH/FSH was more than 2:1in cases. and a non-significantly higher follicle-stimulating hormone level than the control group. Prolactinlevels were normal. Conclusion: The findings of the study showed that PCOS is associated with hypothyroidism and other hormonal imbalance as compared to normal population. So Hormonal dysfunctions in PCOS manifested together or independently. PCOS women can be sub grouped based on clinical features suggestive of endocrinological malfunctions and can be investigated accordingly for selection of appropriate treatment modalities
- Sirmans SM, Pate KA. Epidemiology, diagnosis and management of polycystic ovary syndrome. Clin Epidemiol 2013;6:1-13.
- Teede H, Deeks A, Moran L (2010). \"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan\". BMC Med8 (1): 41. doi:10.1186/1741-7015-8-41. PMC 2909929.PMID 20591140.
- Williamson K, Gunn AJ, Johnson N, Milsom SR. The impact of ethnicity on the presentation of polycystic ovarian syndrome. Aust N Z J Obstet Gynaecol 2001;41:202 6
- Dahiya K, Sachdeva A, Singh V, Dahiya P, Singh R , Dhankhar R, Ghalaut P, Malik I . Endocrinol 2012;3(6):WMC003455
- Ghosh S, Kabir SN, Pakrashi A, Chatterjee S, Chakravarty B. Subclinical hypothyroidism: A determinant of polycystic ovary syndrome. Horm Res. 1993;39:61?6
- Kedar KV, Rewatkar MM, Akare MD. Thyroid dysfunction in women with polycystic ovarian syndrome: A comparative study. Int J Reprod Contracept Obstet Gynecol 2019;8:1943-5.
- Moustafa MM, Jamal MY and Al-Janabi RD Thyroid hormonal changes among women with polycysticovarian F1000Research 2019, :669 (syndrome in Baghdad ? a case-control study [version 1; peer review: awaiting peer review]
- Wakim AN, Polizotto SL, Burholt DR. Augmentation by thyroxine of human granulosa cell gonadotrophin- induced steroidogenesis. Hum Reprod. 1995;10:2845?8.
- Poppe K, Glinoer D. Thyroid autoimmunity and hypothyroidism before and during pregnancy. Hum 10.Krassas GE. Thyroid disease and female reproduction. Fertility and sterility.2000; 74(6):1063-70
- Reprod update 2003;9:149-61. 23. Thomas R, Reid RL. Thyroid disease and reproductive dysfunction: a review. Obst Gynae 1987;70(5):789-98.
- Yildiz BO, Azziz R. The adrenal and polycystic ovary syndrome. Rev Endocr Metab Disord 2007;8:331-42.
- Deshmukh S. Polycystic ovarian syndrome. In: Allahbadia GN. Infertility management made easy.Tunbridge Wells: Anshan Ltd; 2007. pp. 172?197
- Nath CK, Barman B, Das A, Rajkhowa P, Baruah P, Baruah M, Baruah A J Family Med Prim Care. 2019 Jan;8(1):256-260. doi: 10.4103/jfmpc.jfmpc_281_18. Prolactin and thyroid stimulating hormone affecting the pattern of LH/FSH secretion in patients with polycystic ovary syndrome: A hospital-based study from North East India.
- IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 5 Ver. VI (May. 2015), PP 6.
[K. Venkateswarlu and A. Padmavijayasree (2019); A STUDY OF ESTIMATION OF TSH,PROLACTIN, FSH AND LH HORMONE LEVELS IN PCOS Int. J. of Adv. Res. 7 (Oct). 1365-1368] (ISSN 2320-5407). www.journalijar.com
KURNOOL MEDICAL COLLEGE