COMPARATIVE STUDY OF IN VITRO ANTHELMINTHIC ACTIVITY OF ETHANOLIC EXTRACTS OF ALLIUM TUBEROSUM ROTTLER EX SPRENG. AND TRIGONELLA FOENUM GRAECUM L. ON INDIAN EARTHWORM.
- Post graduate junior resident, Department of Pharmacology Regional Institute of Medical Sciences, Imphal, Manipur, India.
- Senior resident, Department of Pharmacology,Regional Institute of Medical Sciences, Imphal, Manipur, India.
- Associate Professor, Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
- Abstract
- Keywords
- References
- Cite This Article as
- Corresponding Author
Helminths have infested human since the era of our earliest recorded history. As per the global estimate for the year 2010 about 465 million people were infested with round worms, hookworms, whipworms etc. So keeping this in our mind, a comparative study was done using ethanolic extracts of Allium tuberosumRottler ex Spreng. (ATR) and Trigonellafoenumgraecum L. (TFG) plants for anthelmintic activity using Indian earthworm (Pheretimaposthuma). Earthworms of 10-12 cm in length were washed with normal saline and divided into 6 groups with 6 earthworms in each group. Gum acacia 2% was used as control (group 1), albendazole suspension (20 mg/ml) as standard (Group 2), ATR 20 mg/ml and 40 mg/ml as group 3 and 4 and TFG 20 mg/ml and 40 mg/ml as group 5 and 6. Time of paralysis and death of individual earthworms was recorded. The plants showed significant anthelminthic activity. Both ATR and TFG at 20 mg/ml & 40 mg/ml doses respectively showed comparable values in time of paralysis and time of death but less potent when compared to standard drug (p<0.001).
- Faust EC, Russell PF, Jung RC, editors. Craig and Faust?s clinical parasitology. 8th edition. Philadelphia: Lea &Febiger; 1970.
- Cox FEG. History of human parasitology. ClinMicrobiol Rev 2002;15(1):595-612.
- Hotez PJ, Ottesen E, Fenwick A, Molyneux D. The neglected tropical diseases: the ancient afflictions of stigma and poverty and the prospects for their control and elimination. AdvExp Med Biol 2006;582(1):23-33.
- Hotez PJ. Forgotten people and forgotten diseases, the neglected tropical diseases and their impact on global health and development: ASM Press; 2008
- Pullan RL, Smith JL, Jasrasaria R, Brooker SJ. Global numbers of? infection? and? disease? burden? of? soil transmitted? helminth? infections? in? Parasit Vectors 2014;7(37):1-19.
- Brooker S, Clements A, Bundy DAP. Global epidemiology, ecology and control of soil-transmitted helminth infections. AdvParasitol 2006;62(1):223-65.
- Bundy DAP, de Silva NR. Can we deworm this wormy world? Br Med Bull 1998;54(1):421-32.
- De Silva NR, Brooker S, Hotez PJ, Montressor A, Engels D, Savioli L. Soil-transmitted helminth infections: updating the global picture. Trend Parasitol 2003;19:547-51.
- Yumnam RS, Onita CH, Abujam SKS, Chetia D. Study on the Ethnomedicinal System of Manipur. IJPBA 2012;3(3):587-91.
- Sultana F, Mohsin M. Nutritional Screening of Allium tuberosum from Western Himalayan Region of India. Int J of Sci and Res 2012;1(1):727-31.
- Valette G, Sauvaire Y, Braccou TC, Ribes G. Hypercholesterolemic effects of fenugreek seeds in dogs. Atherosclerosis 1984;51(1):105-11.
- D. Vidyarthi. A Textbook of Zoology. 14th edn. New Delhi: S. Chand and Co; 1977.
- W. Thorn, R.D.Adams, E.Brundwald, K.J. Isselbacher, R.G.Petersdorf, editors. Harrison's Principles of Internal Medicine. New York: McGrow Hill; 1977.
- Vigar. Atlas of Medical Parasitology. 2ndedn. Singapore: P.g. Publishing House.
- G.Mali, J.C.Hundiwale, R.S.Sonawane. Indian J Nat Prod 1995;14(1):11.
[Tarun Kumar, A. Pfuzia, Priyotosh Banerjee, Priyadarshini Shougrakpam and P. Shyamasakhi Devi. (2018); COMPARATIVE STUDY OF IN VITRO ANTHELMINTHIC ACTIVITY OF ETHANOLIC EXTRACTS OF ALLIUM TUBEROSUM ROTTLER EX SPRENG. AND TRIGONELLA FOENUM GRAECUM L. ON INDIAN EARTHWORM. Int. J. of Adv. Res. 6 (Dec). 491-494] (ISSN 2320-5407). www.journalijar.com
Senior resident
