22Dec 2018

EFFECTIVENESS OF INTRALESIONAL DEXAMETHASONE AND HYALURONIDASE IN ORAL SUBMUCOSAL FIBROSIS (A RETROSPECTIVE STUDY).

  • senior resident ENT dr Ulhaspatil medical college.
  • senior resident ENt Skims medical college Srinagar.
  • senior resident ENT dr ulha spatil medical college jalgaon.
  • associate professor ENT dr ulhaspatil medical college jalgaon.
  • paikay HOD deptt of ENT dr ulhas patil medical college.
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oral submucous fibrosis is an insidious progressive painless oral cavity disease which is characterized by juxtaepithelial deposition of of fibrous tissue that sometimes even extend to pharynx.The majority of patients present with gradually progressive painless difficulty in opening the mouth.The disease may advance and cause difficulty in in protruding out the tongue.Although the medical treatment is not completely systematised,optimal dose of its treatment with local injection of corticosteroids with hyluronidase or placentral extract is effective in some extent.However a combination of steroids and topical hyaluronidase shows better long term results than than either agents usedindividually. Material and methods:the study was conducted at DrUlhaspatil medical college from jan 2017 to jan 2018.A total of 30 patients were included in the study. They were treated by administering an intralesional injection of dexamethasone 1.5 ml, hyluronidase1500 IU with 0.5ml lignocaineHCL,injectedintralesionally biweekly for 4 weeks Results:patients mouth opening was was improved by net gain of 5+_2m , the range being 5-7mm. Definite reduction in the burning sensation,painful ulceration and blanching of oral mucosa and patient followed up for an average of one year. Conclusion:injection of hyluronidase with dexametasoneia an effective method of managing ngrade 111 OSMF

  1. R.pillai, p.Balram,and K.S. Reddiar, pathogenesis of oral submucous fibrosis; releationship to risk factors associated with oral cancer,Cancer ,vol.69,no.8,pp.2011-2020,1992.
  2. V.V. shevale and R.D. Karla,management of oral Submucousfibrosis;a review, Indian journal of Dental sciences,vol 4,no,2,2012.
  3. R.M. Borle,P.VNimonkar, and R. Rajan, Extended nasolabial flaps in the management of oral submucousfibrosis.British journal of oral and maxillofacial surgery,vol 47,no.5,pp.382-385,2009.
  4. Borle RM, Borle SR, Management of oral submucous fibrosis: a conservative approach.J oral maxillofacsurg 1991:49(8):788-91
  5. Martin H, Koop EC.Precancerous mouth lesions of avitaminosis B Am J surg 1942;57:195.
  6. Gupta D sharmaSC.oralsubmucous fibrosis a new treatment regimen. J oral maxillofacSurg 1988;46(10):830-3
  7. Le PV, Gornitssky M, Domanowski G. Oral stent as treatment adjunct for oral submucous fibrosis. Oral surg oral med oral patho oral radiolEndod 1996:81(2):148-50
  8. Pindborg JJ, Sirsat SM. Oral submucousfibrosis.Oralsurg Oral Med oral pathol1996:22(6):764-79
  9. Pindbrog JJ, Mehta FS, Daftary DK, occurrence of epithelial atypia in 51 Indian villagers with oral submucous fibrosis. Br J Cancer1970;24(2):253-7.
  10. SinhaSN,Jain PK. Intra oral injection of hydrocortisone and placentral extract in oral submucous fibrosis. Indian Jotolaryngol 1978;30(2);103. Lai DR, Chen HR, Lin LM, .Haung YL, Tsai CC. clinical evaluation of different treatment methods for oral submucosal fibrosis. J. oral pathol med1995;24(9);402-6
  11. Haque MF. Meghi S, Nazir R. Interferon gamma may reverse oralsubmucous fibrosis. J oral pathol Med2011;30;12-21 Fame JW, Carbondioxidelasere surgery for benign oral lesions.Br Dent J 1985;158(4);125-8
  12. Strong MS, Jako GJ, Polanyi T, Wallace RA. Laser surgery in aerodigestive tract. Am J Surg1973;126(4):529-33
  13. Bradley PF.A review of the use of the neodymium YAG laser in oral and maxillofacial surgery. Br J oral MaxillofacSurg 1997;35(1);26-35
  14. White JM, Chaudary SI, Kudler JJ, Sekandari N, Schoelch ML, Silverman s jr.Nd:YAG and Co2 laser therapy of oral mucosal lesions . J Clin Laser Med Surg 1998;16(6);299-304 .

[Shahnaz Sheikh, Asif Mahajan, Vikranth Vaze, Anushree Bajaj And Balchandra Paikay. (2018); EFFECTIVENESS OF INTRALESIONAL DEXAMETHASONE AND HYALURONIDASE IN ORAL SUBMUCOSAL FIBROSIS (A RETROSPECTIVE STUDY). Int. J. of Adv. Res. 6 (Dec). 1246-1248] (ISSN 2320-5407). www.journalijar.com

Dr Anushree Bajaj
Associate Professor ENT Dr Ulhas Patil Medical College Jalgaon

DOI:

Article DOI: 10.21474/IJAR01/8259      
DOI URL: https://dx.doi.org/10.21474/IJAR01/8259

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