04Jan 2018

INVESTIGATION OF C. LONGA LEAVES FOR IMMUNOMODULATION: A PRELIMINARY STUDY.

  • Research Scholar, (Corresponding Author), Maulana Azad National Institute of Technology, Bhopal.
  • Professor, Head, Deptt. Of Chemistry, Maulana Azad National Institute of Technology, Bhopal.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Turmeric (Curcuma longa) is a small rhizomatous perennial herb belonging to Zingiberaceae family originating mostly from India. The rhizome has been used widely as a spice, colouring agent and for various therapeutic properties. The leaves of C. longa plant are less explored though they possess therapeutic properties. Aim: Present study was carried out to verify the immunomodulation activity in the methanolic extract of C. longa leaves. Method: Various phytochemicals have been evaluated by the standard methods proposed by Harborne. The antioxidant activity was investigated by DPPH radical scavenging activity, NO scavenging activity and Total antioxidant activity. The antimicrobial activity was investigated by disc diffusion method. Result: The proper working of the immune cells depends on the balance of the antioxidant-oxidant balance. The investigations thus carried out suggested that C. longa leaves is a reliable source of antioxidants and is an excellent antimicrobial agent. The phytochemicals are in abundance in the leaf extracts which supports the antioxidant and antimicrobial properties. Conclusion: The antioxidants and antimicrobial activity are key to the proper functioning of the immune cells and the results clearly suggest that C. longa leaves possess decent antioxidant and antimicrobial activity thus, suggesting that C. longa leaves are potent immunomodulator.

  1. Baxter D.?Active and passive immunity, vaccine types, excipients and licensing.? Med.2007 ,57?552?556.? 10.1093/occmed/kqm110?[PubMed].
  2. Vesely M. D., Kershaw M. H., Schreiber R. D., Smyth M. J. Natural innate and adaptive immunity to cancer.? Rev. Immunol.2011, 29?235?271. 10.1146/annurev-immunol-031210-101324[PubMed].
  3. Ibrahim Jantan,?Waqas Ahmad, and?Syed Nasir Abbas Bukhari. Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci. 2015; 6: 655.
  4. Arokiyaraj, S., Perinbam, K., Agastian, P. and Balaraju, K. Immunosuppressive effect of medicinal plants of Kolli hills on mitogen stimulated proliferation of the human peripheral blood mononuclear cells in In vitro. Indian Journal of Pharmacology, (2007) , 39 (4):180-183.
  5. Njoroge, G.N. and Bussmann, R.W. Diversity and utilization of antimalarial ethnophytotherapeutic remedies among the Kikuyus (central Kenya). Journal of Ethnobiology and Ethnomedicine, (2006), 2:8-14.
  6. Kenneth Omondi Ogila, Antimicrobial and immunomodulatory properties of extracts of Asparagus setaceous Kunth and Caesalpinia volkensii Harm, 2011, Jomo Kenyatta University of Agriculture and Technology, Kenya.
  7. Cordell, J. Natural products in drug discovery- Creating a new wisdom. Phytochemistiy Reviews, (2002), 1: 261 -273.
  8. Liise-anne Pirofski and Arturo Casadevall, Immunomodulators as an antimicrobial tool, Current Opinion in Microbiology ,Volume 9, Issue 5,?October 2006, Pages 489-495.
  9. Makare N., Bodhankar S. and Rangari V., Immunomodulatory activity of alcoholic extract of?Mangifera indica?in mice, Journal of Ethnopharmacology, 2001, 78, 133-137.
  10. Davis, L., Kuttan, G., Immunomodulatory activity of?Withania somnifera. J. Ethnopharmacol. 2000, 71: 193-200.
  11. Tanzeela Nisar et.al. Turmeric: A Promising Spice for Phytochemical and Antimicrobial Activities, American-Eurasian J. Agric. & Environ. Sci., 2015, 15 (7): 1278-1288.
  12. Arutselvi et.al, Phytochemical screening and comparative study of anti-microbial activity of leaves and rhizomes of turmeric varieties, Asian Journal of Plant Science and Research, 2 (2), (2012): 212-219.
  13. Yunbao Liu et.al. Curcuma longa and Curcuma mangga leaves exhibit functional food property, Food Chemistry 135 (2012) 634?640.
  14. Azmir et.al. Techniques for extraction of bioactive compounds from plant materials: A review. Journal of Food Engineering 117 (2013) 426?436.
  15. Morsi RMY, Tahan NREL, El-Hadad AMA, Effect of aqueous extract Mangifera Indica leaves, as functional foods. J Appl Sci Res 6 (2010): 712.
  16. Harbone JB. Phytochemical Methods- A Guide to Modern Techniques of Plant Analysis, Chapman and Hall London, 1998.
  17. Brand-Williams, Cuvelier ME, Berset CLWT. Use of a free radical method to evaluate antioxidant activity. LWT-Food Science and Technology 1995; 28(1):25-30.
  18. Prieto, P., Pineda, M., Aguilar, M. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of Vitamin E1. Anal. Biochem. 1999, 269, 337?341.
  19. CLSI, Performance Standards for Antimicrobial Disk Susceptibility Tests, Approved Standard, 7th ed., CLSI document M02-A11. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012.
  20. Mounyr Balouiri et.al. Methods forin vitro?evaluating antimicrobial activity: A review. Journal of Pharmaceutical Analysis. Volume 6, Issue 2, April 2016, Pages 71?79.
  21. Doughari et.al. Antimicrobial activity of leaf extracts of Senna obtusifolia (L). African Journal of Pharmacy and Pharmacology Vol. 2(1), pp. 007-013, March 2008.
  22. M.Tanvir et.al, Antioxidant Properties of Popular Turmeric?(Curcuma longa)?Varieties from Bangladesh, Journal of Food Quality 31 May 2017, Volume?2017?(2017).
  23. Fialkow L, Wang Y, Downey GP. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function.?Free Radic Biol Med.?2007; 42:153?164. doi: 10.1016/j.freeradbiomed.2006.09.030.?[PubMed][Cross Ref]
  24. M De la Fuente, Effects of antioxidants on immune system ageing, European Journal of Clinical Nutrition (2002) 56, Suppl 3, S5?S8.
  25. Rubilar?M,?Jara?C,?Poo?Y,?Acevedo?F,?Gutierrez?C,?Sineiro?J,?Shene?C.?Extracts of Maqui (Aristotelia chilensis) and Murta (Ugni molinae Turcz.): sources of antioxidant compounds and?α-Glucosidase/α-Amylase inhibitors. J Agric Food Chem.2011, 59:1630?1637. doi:?1021/jf103461k[Crossref],?[PubMed],?[Web of Science ?],?Google Scholar.

[Shikha Rana and Savita Dixit. (2018); INVESTIGATION OF C. LONGA LEAVES FOR IMMUNOMODULATION: A PRELIMINARY STUDY. Int. J. of Adv. Res. 6 (Jan). 309-316] (ISSN 2320-5407). www.journalijar.com

Shikha Rana

DOI:

Article DOI: 10.21474/IJAR01/6220      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6220

Download Full Paper

Download PDF No. of Downloads: 3 | No. of Views: 62