16Dec 2017

POLYCYSTIC OVARIAN SYNDROME IN WOMEN WITH OBESITY.

Crossref Cited-by Linking logo

Plum Print visual indicator of research metrics
  • Captures
    • Readers: 4
see details

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Introduction: Obesity becomes a recent worldwide epidemic and it is close associated with PCOS. Currently there are not enough researches which can let to understand the interplay between PCOS and its features including anovulation and infertility and androgen status and obesity. The aim of the study was to identify relations between PCOS and obesity. Methodology: Cross-sectional study was conducted for the period 2014-2016 and included 300 of patients with PCOS. The following categorical variables were studied: age, marital status, weight, BMI, family history, frequency of irregular periods, subfertility, hirsutism, acne, skin hyperpigmentation. The analyses were performed using the SPSS package version 17.0 (SPSS Inc., Chicago, IL, USA). Results and conclusion: Current research showed that non-obese women with PCOS more often had family history of PCOS and were significantly more likely to have such symptoms as irregular menses, hirsutism, acne vulgaris and recurrent miscarriages than women with obesity and PCOS. However there is a need for more researches regarding to risk factors, etiology and pathogenesis of PCOS in order to identify the underlying causes.

  1. Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop. (2012). Consensus on women's health aspects of polycystic ovary syndrome (PCOS). Hum Reprod., 27:14-24.
  2. Barthelmess, E.K., Naz, R.K. (2015). Polycystic ovary syndrome: current status and future perspective. Front Biosci (Elite Ed), 6:104-119.
  3. Carmina, E., Oberfield, S.E., and Lobo, R.A. (2010). The diagnosis of polycystic ovary syndrome in adolescents. Am J Obstet Gynecol., 203:201.e1-201.e5.
  4. Caserta, D., Adducchio, G., Picchia, S., Ralli, E., Matteucci, E., and Moscarini, M. (2014). Metabolic syndrome and polycystic ovary syndrome: an intriguing overlapping. Gynecol Endocrinol., 30(6):397-402.
  5. Chen, Z.J., Zhao, H., He, L., Shi, Y., Qin, Y., Shi, Y., Li, Z., You, L., Zhao, J., Liu, J., Liang, X., Zhao, X., Zhao, J., Sun, Y., Zhang, B., Jiang, H., Zhao, D., Bian, Y., Gao, X., Geng, L., Li, Y., Zhu, D., Sun, X., Xu, J.E., Hao, C., Ren, C.E., Zhang, Y., Chen, S., Zhang, W., Yang, A., Yan, J., Li, Y., Ma, J., and Zhao, Y. (2011). Genome-wide association study identifies suspectibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, 9q33.3. Nat Genet., 43:55-59.
  6. Conway, G., Dewailly, Didier., Diamanti-Kandarakis, E., Escobar-Morreale, H.F., Franks, S., Gambineri, A., Kelestimur, F., Macut, D., Micic, D., Pasquali, R., Pfeifer, M., Pignatelli, D., Pugeat, M., and Yildiz, B.O. (2014). The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. European Journal of Endocrinology, 171, P1-P29.
  7. Dedov, I.I., Melnichenko, G.A., and Butrova, S.A. (2006). Adipose tissue as an endocrine organ. Obesity and Metabolism, 1, 6-13.
  8. De Ugarte, C.M., Woods, K.S., Bartolucci, A.A., and Azziz, R. (2006). Degree of facial and body terminal hair growth in unselected black and white women: toward a populational definition of hirsutism. J Clin Endocrinol Metab., 91:1345-1350.
  9. Hoeger, K.M., Oberfield, S.E. (2012). Do women with PCOS have a unique predisposition to obesity? Fertil Steril., 97(1):13-7.
  10. Legro, R.S. (2012). Obesity and PCOS: Implications for Diagnosis and Treatment. Semin Reprod Med., 30(6): 496-506.
  11. Lim, S.S., Davies, M.J., Norman, R.J. and Moran, L.J. (2012). Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction Update, 18(6), 618?637.
  12. Messinis, I.E., Messini, C.I., Anifandis, G., and Dafopoulos, K. (2015). Polycystic ovaries and obesity. Best Pract Res Clin Obstet Gynaecol., 29(4):479-88.
  13. Metwally, M., Ong, K.J., Ledger, W.L., and Li, T.C. (2008). Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril., 90:714-726.
  14. Mortada, R., Williams, T. (2015). Metabolic Syndrome: Polycystic Ovary Syndrome. FP Essent., 435:30-42.
  15. Motta, A.B. (2012). The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des., 18(17):2482-91.
  16. Naderpoor, N., Shorakae, S., Joham, A., Boyle, J., De Courten, B., and Teede, H.J. (2015). Obesity and polycystic ovary syndrome. Minerva Endocrinol., 40(1):37-51.
  17. Nandi, A., Chen, Z., Patel, R., and Poretsky, L. (2014). Polycystic ovary syndrome. Endocrinol Metab Clin North Am., 43(1):123-47.
  18. Pandey, P., Maheshwari, A., and Bhattacharya, S. (2010). Should access to fertility treatment be determined by female body mass index? Hum Reprod., 25:815-820.
  19. Park, Y.W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M.R., and Heymsfield, S.B. (2003). The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Int Med., 163:427-436.
  20. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop. (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod., 19:41-47.
  21. Spritzer, P.M. (2014). Polycystic ovary syndrome: reviewing diagnosis and management of metabolic disturbances. Arq Bras Endocrinol Metab., 58(2), 182-187.
  22. Talmor, A., Dunphy, B. (2015). Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol., 29(4):498-506.
  23. Vahratian, A., Smith, Y.R. (2009). Should access to fertility-related services be conditional on body mass index? Hum Reprod Update., 24:1532-1537.
  24. Zhao, H., Xu, X., Xing, X., Wang, J., He, L., Shi, Y., Shi, Y., Zhao, Y., and Chen, Z.J. (2012). Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Hum Reprod., 27:294-298.
  25. Zhao, X., Zhong, J., Mo, Y., Chen, X., Chen, Y., and Yang, D. (2010). Association of biochemical hyperandrogenism with type 2 diabetes and obesity in Chinese women with polycystic ovary syndrome. Int J Gynaecol Obstet., 108:148-151.

[Alanazi, Abdul Aziz Ahmed N. (2017); POLYCYSTIC OVARIAN SYNDROME IN WOMEN WITH OBESITY. Int. J. of Adv. Res. 5 (Dec). 793-796] (ISSN 2320-5407). www.journalijar.com

ALANAZI
MEDICAL STUDENT ( JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY)

DOI:

Article DOI: 10.21474/IJAR01/6021      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6021

Download Full Paper

Download PDF No. of Downloads: 3 | No. of Views: 57