30Dec 2017

ASSESSMENT OF INSULIN RESISTANCE INDEX (HOMA-IR) AND LIPID PROFILE AMONG SUDANESE WOMEN WITH GALLSTONES.

  • Department of Clinical Chemistry, Faculty of Medical Laboratory Science, University of AL-Neelain-Sudan.
  • Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of AL-Neelain -Sudan.
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The aim of this study was to assess insulin resistance index (HOMA-IR) and lipid profile level in Sudanese gallstones (GSs) patients and their association with study variables. In case control study 80 clinically diagnosed GSs patients were recruited, and 80 apparently health age matched women as control group. Fasting insulin, glucose and lipid profile (TC, TG, HDL-C and LDL-C) were measured using TOSOH-311? and Mindray-380? analyzers. IR-index was calculated using HOMA-IR formula. Obese postmenopausal women had higher GS (62.5%). HOMA-IR, TC, LDL-C and TG level were significantly increased in Sudanese women with GS than control group p=0.000, 0.000, 0.000 and 0.000 respectively. Significant positive associations between TC, LDL-C and HOMA-IR were observed p=0.001, r=437 and p=0.001, r=0.419 respectively. BMI also showed positive association with TC, TG and LDL-C. In conclusion, Sudanese females with GSs had higher HOMA-IR, TC, TG and LDL-C. Obesity may be the first risk factor of GS in Sudanese women. Thus could lead to GSs pathogenesis especially in postmenopausal.

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[Nisreen Abdalmuty Abdalrahman and Amar Mohamed Ismail. (2017); ASSESSMENT OF INSULIN RESISTANCE INDEX (HOMA-IR) AND LIPID PROFILE AMONG SUDANESE WOMEN WITH GALLSTONES. Int. J. of Adv. Res. 5 (Dec). 1685-1690] (ISSN 2320-5407). www.journalijar.com

Amar Mohamed Ismail
Al-Neelain University - Faculty of Science and Technology

DOI:

Article DOI: 10.21474/IJAR01/6135      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6135

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