15Nov 2017

GLUTATHIONE AND ITS IMPLICATIONS DURING CANDIDA INFECTIONS IN HUMANS.

  • Centre of research for development (CORD) University of Kashmir, Srinagar, Jammu and Kashmir, 190006, India.
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Candida spp. is known for their commensal behavior in humans and animals and studies involving the role of this fungus in adaptation and interaction with the host are also well known. Sometimes, in immunocompromised patients, this Candida (Candida albicans and Candida glabrata) causes superficial and systemic infections in humans known as mycosis and candidiasis respectively. During pathogenesis, Candida infect the host cells and evade the host immune response, while the host phagocytes secrete reactive oxygen species (ROS), reactive nitrogen species (RNS), hydrolytic enzymes and antimicrobial peptides to combat and eliminate these pathogens form the host cells. Moreover, antifungals are also known to induce ROS. In response to these oxidant killing pathways of host, Candida has developed antifungal strategies to maintain redox homeostasis and escape the antifungal response of the host. Glutathione pathway has been known as the central pathway in maintaining redox balance in yeast. The recent literature has shown an increasing trend in connecting the antifungal response with redox homeostasis in fungal pathogens. In this review, we present an updated knowledge about the recent findings in glutathione pathway involved in Candida survival and pathogenesis.

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[Shabir Ahmad Bhat and *Ajaz Ahmad Waza. (2017); GLUTATHIONE AND ITS IMPLICATIONS DURING CANDIDA INFECTIONS IN HUMANS. Int. J. of Adv. Res. 5 (Nov). 692-696] (ISSN 2320-5407). www.journalijar.com

Dr. Ajaz Ahmad Waza
Centre of research for development (CORD) University of Kashmir, Srinagar, Jammu and Kashmir, 190006, India.

DOI:

Article DOI: 10.21474/IJAR01/5822      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5822

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