29Nov 2017

POSSIBLE PROTECTIVE EFFECT OF VITAMIN E ON BISPHENOL - A INDUCED CHANGES OF THE MALE REPRODUCTIVE SYSTEM OF ADULT ALBINO RATS: HISTOLOGICAL STUDY.

  • Reproductive Physiology Lab, Dept. of Zoology, University of Rajasthan, Jaipur.
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Background: Bisphenol A (BPA) is an abundantly used xenoestrogenic chemical, a contaminant of polycarbonate plastics, resin-based dental composites and sealants, which cause various reproductive disorders. Objective: The aim of the study is to evaluate the adverse effect of BPA, on accessory reproductive organs (epididymis, vas deferens, seminal vesicle and prostate) of male reproductive system. Protective effect of vitamin E on deleterious outcomes of BPA also evaluated. Material and Methods: Adult male Wistar albino rats aged 3 weeks were randomly divided into ten groups: control group (olive oil treated) BPA group (dose 5, 50,100 ?g/100g BW) and vitamin E intervention group (dose 5, 50,100 ?g/100g BPA+ vitamin E 4mg/100gbw) and recovery group. Animals were sacrificed 3 months later, blood and tissue samples were collected. Results: A significant reduction in the epididymis and seminal vesicle weight was observed whereas prostate showed weight significant increment. A degenerative change in epithelium of epidiymis was observed whereas, other reproductive organs dose not showed any adverse histopathological change in the BPA group as compared with the control and vitamin E intervention group. All these changes were attributed to disrupted spermatogenesis that would interfere with sperm production which is confirmed by decreased sperm count. Root cause behind all these effects is decrement in testosterone level by BPA treatment. No changes were observed in recovery group animals. Conclusion: BPA exposure causes various fertility problems by effecting hormonal level, sperm count, weight and histology of reproductive organs. On the other hand supplementations of vitamin E have certain protective effect on reproductive dysfunction caused by BPA. Thus, it could have a protective role in improving male fertility.

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[Seema Srivastava, Priya Gupta and Noopur Dhagga. (2017); POSSIBLE PROTECTIVE EFFECT OF VITAMIN E ON BISPHENOL - A INDUCED CHANGES OF THE MALE REPRODUCTIVE SYSTEM OF ADULT ALBINO RATS: HISTOLOGICAL STUDY. Int. J. of Adv. Res. 5 (Nov). 977-991] (ISSN 2320-5407). www.journalijar.com

Dr Seema Srivastava
Department of Zoology, University of Rajasthan, Jaipur (rajasthan) India

DOI:

Article DOI: 10.21474/IJAR01/5857      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5857

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