31Oct 2017

CYTOGENETICS AND MOLECULAR EVIDENCE OF ANOVULATORY INFERTILITY.

  • Department of Zoology, Sree Narayana College, Cherthala- 688582, Kerala.
  • Research Scholar, Meenakshi University, West K K Nagar, Chennai, Tamil Nadu.
  • HOD, Assistant professor, Department of Zoology, Sree Narayana College, Cherthala- 688582, Kerala.
  • Genetika, Centre for Advanced Genetic Studies, Pettah P O, Thiruvananthapuram - 695024, Kerala.
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Anovulation is probably the major cause of human infertility and it affects between 6% and 15% of all women of childbearing age. One of the cardinal signs of anovulation is irregular or absent menstrual periods. The aim of the present study was to investigate the cytogenetics and molecular evidence of anovuatory infertility. The present study was carried out in 52 subjects suffering from anoulatory infertility and 18 age matched subjects as control. The cytogenetic and molecular analysis of study subjects were correlated with various demographic, clinical and lifestyle aspects. Lymphocyte culture and cytokinesis-block micronuclei (CBMN) assay was also carried out in each subject. The study demonstrated that the micronuclei frequency significantly elevated in the study subjects than control subjects. Anovulatory women with various risk factors such as advancing age, duration of married life, occupation, BMI, age at menarche, family history of PCOS and family history of infertility etc. can lead to increased genetic instabilities. Subjects having abnormal level in reproductive hormones were also showed abnormal chromosome pattern. Subjects with increased genetic instabilities and abnormal karyotype may leads to severity of infertility. Change in lifestyle such as food habit, exercise, weight management, reducing psychological stress etc. is the best treatment options for reproductive health.

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[Athira Sundar, Arun William, Sanuj C Breezevilla and Dinesh Roy D. (2017); CYTOGENETICS AND MOLECULAR EVIDENCE OF ANOVULATORY INFERTILITY. Int. J. of Adv. Res. 5 (Oct). 2011-2015] (ISSN 2320-5407). www.journalijar.com

Dr. Dinesh Roy D
Genetika, Centre for Advanced Genetic Studies

DOI:

Article DOI: 10.21474/IJAR01/5728      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5728

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