27Sep 2017

EFFECTIVENESS OF 2% CHLORHEXIDINE ON REMOVAL OF E.FAECALIS BIOFILM IN ROOT CANAL: A SYSTEMATIC REVIEW.

  • Department of Conservative Dentistry and Endodontics, Dr. D. Y. Patil Vidyapeeth (DPU), DR. D. Y. Patil Dental College and Hospital, Pimpri, Pune-18
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Objective : The aim of this systematic review was to systematically gather and evaluate the adjunctive effect of 2% chlorhexidine on removal of E.faecalis biofilm in root canal. Data Sources : A systematic search was conducted using MEDLINE PubMed, Google Scholar and manual search using DPU College library resources were searched up to and including 31st December 2015 to identify appropriate studies. Study eligibility criteria : In vitro and Comparative studies were selected; however, only articles where the effect of 2% Chlorhexidine on removal of E. Faecalis biofilm in root canal in freshly extracted human teeth were included. Review, case reports, abstracts , letters to editors, editorials were excluded. In vivo studies were excluded. Participants : Participants were comprised of freshly extracted human teeth. Interventions : Subjects irrigated with 2% CHX along with other irrigants in all the studies. Results : Total 1632 articles were identified through the database searching and 4 articles were identified through other sources.1636 articles were selected and records were assessed for any duplicates. 1608 articles were removed and 28 articles were screened for full text. Out of these, 21 articles were selected and were assessed for eligibility. Only 7 articles were qualified and 14 articles were excluded. 2% CHX showed statistically better results in 5studies. Conclusions : The disinfection of the root canal system produced by action of CHX reduces the remaining endodontic microbiota, achieving of a higher level of success of the endodontic treatment. Key Words: Chlorhexidine, E.faecalis biofilm, Biofilm Removal, endodontic irrigant.

  1. -S. He and W.-Y. Shi, ?Oral microbiology: past, present and future,? International Journal of Oral Science, vol. 1, no. 2, pp.47?58, 2009.
  2. N. R. Nair, ?On the causes of persistent apical periodontitis: a review,? International Endodontic Journal, vol. 39, no. 4, pp. 249?281, 2006.
  3. 3: F. Siqueira Jr. and I. N. R?oc?as, ?Clinical implications and microbiology of bacterial persistence after treatment procedures,?Journal of Endodontics, vol. 34, no. 11, pp. 1291?e3, 2008.
  4. 4: Haapasalo M, Shen Y, Qian W, Gao Y (2010) Irrigation in endodontics. Dent Clin North Am 54, 291-312.
  5. 5: Spangberg L, Engstr?m B, Langeland K (1973) Biologic effects of dental materials. 3. Toxicity and antimicrobial effect of endodontic antiseptics in vitro. Oral Surg Oral Med
  6. Oral Pathol 36, 856-871.
  7. 6: Berber VB, Gomes BP, Sena NT, Vianna ME, Ferraz CC, Zaia AA et al. (2006) Efficacy of various concentrations of NaOCl and instrumentation techniques in reducing Enterococcus faecalis within root canals and dentinal tubules. Int Endod J 39, 10-17.
  8. 7: Sirtes G, Waltimo T, Schaetzle M, Zehnder M (2005) The effects of temperature on sodium hypochlorite short-term stability, pulp dissolution capacity, and antimicrobial efficacy. J Endod 31, 669-671.
  9. 8: Mercade M, Duran-Sindreu F, Kuttler S, Roig M, Durany N (2009) Antimicrobial efficacy of 4.2% sodium hypochlorite adjusted to pH 12, 7.5, and 6.5 in infected human root canals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107, 295-298.
  10. 9: Jeansonne MJ, White RR (1994) A comparison of 2.0% chlorhexidine gluconate and 5.25% sodium hypochlorite as antimicrobial endodontic irrigants. J Endod 20, 276-278.
  11. 10: Greenstein G, Berman C, Jaffin R (1986) Chlorhexidine. An adjunct to periodontal therapy. J Periodontol 57, 370-377.
  12. 11: White RR, Hays GL, Janer LR (1997) Residual antimicrobial activity after canal irrigation with chlorhexidine. J Endod 23,229-231.
  13. 12: Ro` c?as IN, Siqueira JF Jr, Santos KR. Association of Enterococcus faecalis with different forms of periradicular diseases. J Endod 2004;30:315?20.
  14. 13: Siwek J, Gourlay ML, Slawson DC, Shaughnessy AF. How to write an evidence-based clinical review article. Am Fam Physician. 2002;65:251-8.
  15. 14: Law A, Messer H. An evidence-based analysis of the antibacterial efficacy of intracanal medicaments. J Endod. 2004;30:689-94.
  16. 15: Mohammadi Z, Shahriari S. Residual antibacterial activity of chlorhexidine and MTAD in human root dentin in vitro. J Oral Sci. 2008 Mar;50(1):63-7.
  17. 16: Mehrvarzfar P, Saghiri MA, Asatourian A, Fekrazad R, Karamifar K, Eslami G, Dadresanfar B. Additive effect of a diode laser on the antibacterial activity of 2.5% NaOCl, 2% CHX and MTAD against Enterococcus faecalis contaminating root canals: an in vitro study. J Oral Sci. 2011 Sep;53(3):355-60.
18.??? 17: Murad et al. Antimicrobial activity of sodium hypochlorite, chlorhexidine and MTAD? against Enterococcus faecalis biofilm on human dentin matrix in vitro. RSBO. 2012 Apr-Jun;9(2):143-50.19.??? 18: Hasheminia S, Farhad AR, Saatchi M, Rajabzadeh M. Synergistic antibacterial activity of chlorhexidine and hydrogen peroxide against Enterococcus faecalis. J Oral Sci. 2013;55(4):275-80.20.??? 19: Valera MC, Maekawa LE, de Oliveira LD, Jorge AO, Shygei ?, Carvalho CA. In vitro antimicrobial activity of auxiliary chemical substances and natural extracts on Candida albicans and Enterococcus faecalis in root canals. J Appl Oral Sci. 2013 Mar-Apr;21(2):118-23.21.??? 20: Mar?a Ferrer-Luque C, Teresa Arias-Moliz M, Ru?z-Linares M, Elena Mart?nez Garc?a M, Baca P. Residual activity of cetrimide and chlorhexidine on Enterococcus faecalis-infected root canals. Int J Oral Sci. 2014 Mar;6(1):46-9.
  1. 21: Noites R, Pina-Vaz C, Rocha R, Carvalho MF, Gon?alves A, Pina-Vaz I. Synergistic antimicrobial action of chlorhexidine and ozone in endodontic treatment. Biomed Res Int. 2014; 2014:592423.

[Mubssira Shaikh, Pradeep Shetty, Monika Chawla and Ekta Senga, Sharon Coelho and Neha Neekhara. (2017); EFFECTIVENESS OF 2% CHLORHEXIDINE ON REMOVAL OF E.FAECALIS BIOFILM IN ROOT CANAL: A SYSTEMATIC REVIEW. Int. J. of Adv. Res. 5 (Sep). 1388-1394] (ISSN 2320-5407). www.journalijar.com

Dr.Mubssira Shaikh
Post Graduate Student , Department of Conservative Dentistry and Endodontics

DOI:

Article DOI: 10.21474/IJAR01/5457      
DOI URL: http://dx.doi.org/10.21474/IJAR01/5457

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