RENAL AMYLOIDOSIS SECONDARY TO UNDIFFERENTIATED CONNECTIVE TISSUE DISORDERS: A RARE CASE REPORT FROM INDIA.

Introduction: The undifferentiated connective tissue disease (UCTD) are the type of clinical entity where the patients share the clinical symptoms of different connective tissue diseases but do not exactly fit into any particular classification criteria of a particular connective tissue disease. Amyloidosis as such secondary to vasculitis is common but those subsequent to undifferentiated vasculitis is not so common entity .Here we are presenting one such interesting case from India. Case details: We present about a patient of 47 years non-smoker male patient who was a known case of peripheral vascular disease underwent right popliteal bypass , right 2nd toe amputation , left below knee amputation and left brachioradial bypass due to frost bite. He was admitted in our hospital with complaints of multiple vomitingsand generalized weakness ,fever and poor oral intake since 3-4 days.His serum ANA/ANF by EIA was moderately positive ,Lupus anticoagulant by DRVVT method is positive ,serum lupus like anticoagulant is positive ,PT 25.2 secs ,INR 2.60 APTT raised 38.3 secs, 24 hours urinary protein 16121 mg/24 hours , Renal biopsy showed amyloidosis, Doppler scan showed common femoral artery and superficial femoral artery has biphasic flow pattern ,suggestive of distal obstruction ,popliteal artery and anterior tibial artery ,show diminished collateralized flow pattern ,no flow seen in posterior tibial artery and dorsalispedis artery. Discussion: Renal amyloidosis can occur as secondary to Undifferentiated connective tissue disorder as one of the complication due to chronic inflammation. Early diagnosis helps in reducing mortality.