30Dec 2017

FUNCTIONALIZATION OF ALGINATE VIA PHOSPHORIZATION: PREPARATION, CHARACTERIZATION.

  • Physical Department, Faculty of Education, Alexandria University, Alexandria, Egypt.
  • Physics Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
  • Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific research and advanced technology. New Boarg El-Arab City,21934, Alexandria, Egypt.
  • Chemistry Department, Faculty of Science, University of Jeddah, Jeddah, 21589, Saudi Arabia.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

In the current study, Phosphorization of Alginate was done via activation of Alginate with Epichlorohydrin then introduces Orthophosphoric as a source of phosphonic groups. Four different molar ratios of Phosphorization were prepared. Phosphorus content was determined using elemental analysis by EDX unit. Physical characterization including moisture content, and ion exchange capacity was examined and confirm phosphorylation step. The structure of the prepared new alginate derivative was characterized using Electronic spectrum (UV-Vis spectrum), Fourier transform infrared FT-IR, Raman Spectroscopy, thermal gravimetric analysis (TGA), Differential scanning calorimetric (DSC) and Scan electron Microscope (SEM).

  1. Haug. Fractionation of alginic acid. Acta Chem Scand. 13, 601?603 (1959).
  2. Kl?ck, A. Pfeffermann, C. Ryser, P. Gr?hn, B. Kuttler, H. J. Hahn, U. Zimmermann. Biocompatibility of mannuronic acid-rich alginates. Biomaterials, 18, 707?713 (1997).
  3. L. Mi, H.W. Sung, S.S. Shyu. Drug release from chitosan?alginate complex beads reinforced by a naturally occurring cross-linking agent. Carbohydrate Polymers, 48 61?72 (2002).
  4. Orive, S. Ponce, R. M. Hernandez, A. R. Gascon, M. Igartua, J. L. Pedraz. Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates. Biomaterials, 23, 3825?3831 (2002).
  5. L. Drury, D. J. Mooney. Hydrogels for tissue engineering: Scaffold design variables and applications. Biomaterials, 24, 4337?4351 (2003).
  6. Lai, A. AbuKhalil, Q. M. Craig Duncan. The preparation and characterisation of drug-loaded alginate and chitosan sponges. International Journal of Pharmaceutics, 251, 175?181 (2003).
  7. M. Omer, T. M. Tamer, M. A. Hassan, P. Rychter, M. S. Mohy Eldin, N. Koseva. Development of amphoteric alginate/aminated chitosan coated microbeads for oral protein delivery. International Journal of Biological Macromolecules.? 92, 362-370 (2016).
  8. S. Mohy Eldin, A. M. Omer, M.A. Wassel, T.M. Tamer, M.S. Abd-Elmonem, S.A. Ibrahim. Novel smart pH sensitive chitosan grafted alginate hydrogel microcapsules for oral protein delivery: I. Preparation and characterization. Int J Pharm Pharm Sci. 7(10), 320-326 (2015).
  9. S. Mohy Eldin, A. M. Omer, M.A. Wassel, T.M. Tamer, M.S. Abd-Elmonem, S.A. Ibrahim. Novel smart pH sensitive chitosan grafted alginate hydrogel microcapsules for oral protein delivery: II. Evaluation of the swelling behavior. Int J Pharm Pharm Sci, 7 (10), 331-337 (2015).
  10. S. Mohy Eldin, E. A. Kamoun, M. A. Sofan, S. M. Elbayomi. L-Arginine grafted alginate hydrogel beads: A novel pH-sensitive system for specific protein delivery. Arabian Journal of Chemistry. 8, 3, 355-365 (2015).
  11. Ramesh Babu, M. Sairam, K. M. Hosamani, T. M. Aminabhavi. Preparation of sodium alginate?methylcellulose blend microspheres for controlled release of nifedipine Carbohydrate Polymers, 69, pp. 241?250 (2007).
  12. Yakup Arıca, A. ?igdem, A. Ergene, B. G?lay, G. ?mer. Ca-alginate as a support for Pb(II) and Zn(II) biosorption with immobilized Phanerochaete chrysosporium Carbohydrate Polymers, 52, 167?174 (2003).
  13. A. Kamoun, E. S. Kenawy, T. M. Tamer, M.A. El-Meligy, M. S. Mohy Eldin. Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation. Arabian Journal of Chemistry. 8, 1, 38-47 (2015).
  14. J. Franklin, S. A. Douthit, M. A. McClure. Evidence that the algI/algJ gene cassette, required for O acetylation of Pseudomonas aeruginosa alginate, evolved by lateral gene transfer. J Bacteriol, 186, 4759?4773 (2004).
  15. J. Linhardt, S. Claude Hudson. Award address in carbohydrate chemistry. Heparin: structure and activity. J Med Chem, 46 (2003), pp. 2551?2564.
  16. J. Coleman, G. Lawrie, L. K. Lambert, M. Whittaker, K.S. Jack, L. Gr?ndahl. Phosphorylation of alginate: synthesis, characterization, and evaluation of in vitro mineralization capacity. Biomacromolecules, 12, 889?897 (2011).
  17. Boontheekul, H. Kong, D. Mooney. Controlling alginate gels degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials, 26, 2455?2465 (2005).
  18. A. Kang, M. S. Shin, J. W. Yang. Preparation and characterization of hydrophobically modified alginate. Polymer Bulletin, 47, 429?435 (2002).
  19. Galant, A. L. Kj?niksen, G. T. M. Nguyen, K. D. Knudsen, Bo. Nystr?m Altering associations in aqueous solutions of a hydrophobically modified alginate in the presence of β-cyclodextrin monomers. J Phys Chem B. 110(1):190-5 (2006).
  20. Z. Liu, L. X. Cao. Preparation of a superabsorbent resistant to saline solution by copolymerization of acrylic acid with sodium polymannuronate Chinese Journal of Applied Chemistry, 19, 455?458 (2002).
  21. S. Mohy Eldin, A. E. Hashem, A.M. Omer, T. M. Tamer, M. E. Yossuf, M. M. Sabet. Enhancement of solubility and ion exchange capacity of chitosan via N-alkyl sulfonation. Journal de Afrikana, 3(5), 336-349 (2016).
  22. Trabelsi, N. H. M?sakni, H. B. Quada, H. Bacha, S. Roudesli. Partial characterization of extracellular polysaccharides produced by cyanobacterium Arthrospira platensis. Biotechnology and Bioprocess Engineering, 14, 27?31(2009).
  23. Dusseault, S. K. Tam, M. M?nard, S. Polizu, G. Jourdan, L. Yahia, J. P. Halle. Evaluation of alginate purification methods: effect on polyphenol, endotoxin, and protein contamination Journal of Biomedical Materials Research Part A, 76, 243?251 (2006).
  24. Silverstein, F. Webster. Spectrometric Identification or Organic Compound, 44 ? 293 (1997).
  25. Rudolph, W. E. Steger, I. Zur Sulfatokomplexbildung in Aluminiumsulfat ? L?sungen und Hydratschmelzen. Z. Phys. Chem., 172, 31?48 (1991).
  26. G. Daniele, A. De Robertis, C. De Stefano, A. Gianguzza, S. Sammartano. Salt Effects on the Protonation of Ortho-Phosphate Between 10 and 50 ◦C in Aqueous Solution. A Complex Formation Model. J. Solution Chem., 20, 495?515 (1991).
  27. Fang, Y. Liu, S. Jiang, J. Nie, G. Ma. Effect of intermolecular interaction on electrospinning of sodium alginate. Carbohydr. Polym. 85, 276?279 (2011).
  28. Fabia, C. Z. Slusarczyk, A. Gawlowski. Fibres Supermolecular Structure of Alginate Fibres for Medical Aplications Studied by Means of WAXS and SAXS Methods. Text. East Eur. 13(5), 114-117 (2005).

[W. M. Abou-Taleb, G. D. Roston, M. S Mohyeldin, A. M Omer, T. M. Tamer, E. F. Shehata and A. M. Hafez. (2017); FUNCTIONALIZATION OF ALGINATE VIA PHOSPHORIZATION: PREPARATION, CHARACTERIZATION. Int. J. of Adv. Res. 5 (Dec). 1612-1621] (ISSN 2320-5407). www.journalijar.com

T.M .Tamer
Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific research and advanced technology. New Boarg El-Arab City,21934, Alexandria, Egypt.

DOI:

Article DOI: 10.21474/IJAR01/6125      
DOI URL: http://dx.doi.org/10.21474/IJAR01/6125

Download Full Paper

Download PDF No. of Downloads: 32 | No. of Views: 109