EFFECT OF INDIGENOUS SUBSTANCES IN PARINAAM SHOOLA W.S.R. TO DUODENAL ULCER.

A duodenal ulcer is a type of ulcer that occurs in the duodenum, the beginning of the small intestine. The most common cause of duodenal ulcer is a stomach infection associated with the Helicobacter pylori bacteria. Duodenal ulcers are eroded areas in the lining of duodenum, which result in abdominal pain, possible bleeding and other gastrointestinal symptoms. Other risk factors for duodenal ulcers include overuse of alcohol, tobacco, and medications such as aspirin and non-steroidal anti-inflammatory drugs. Severe illness has also been implicated as a risk factor in the development of duodenal ulcer. The signs and symptoms of duodenal ulcer can be constant or sporadic pain, heartburn, severe nausea and vomiting. Patients with duodenal ulcer will complain of pain that awakens them from sleep. Treatment focused on hospitalization, bed rest, and prescription of special bland foods. Antacids and medications that block acid production became the standard of therapy. Despite this treatment, there was a high recurrence of ulcers. Patients with H. pylori infection can be treated with antibiotics. In Ayurveda, the symptoms, etiopathogenesis of duodenal ulcer resembles with Parinaam Shoola. Treatment includes administration of Sanshodhana, Sanshamana, Nidan Parivarjana, Pathya-apathya and prevention of recurrences. The Patoladi Ghanvati along with some indigenous drugs is found to be effective in combating this disease. Total 30 patients diagnosed as Parinaam Shoola (Duodenal Ulcer) of any socio-economic status, age group of 15-70 years and irrespective of sex were randomly selected. The drugs Patoladi Ghanvati was orally given for three month of duration. Patoladi Ghanvati was effective in alleviating the symptoms of Parinaam Shoola. It was observed that the drug is especially effective in early cases of Parinaam Shoola. This beneficial effect of trial drug may be due to its Deepan, Pachan, Pitta-sarak, Udarshool-nashak, Vatanulomak, Anti-inflamatory, Anti-Ulcer, Anti-oxidant, Anti-Stress and Anti-Spasmodic properties.