28Jun 2017

MICROWAVE IRRADIATION SYNTHESIS AND ANTIOXIDANT ACTIVITY OF ISATIN-OXADIAZOLE DERIVATIVES.

  • University College of Technology, Osmania University, Hyderabad-500007, T.S.
  • Department of Chemical Sciences, Osmania University, Hyderabad-500007, T.S.
  • Dept of Chemical Engineering, School of Mechanical, Chemical and Materials Engineering, Adama Science and Technology University, Adama, Ethiopia.
  • Centre for Pharmaceutical Sciences, Institute of Science and Technology, JNTUH.
  • Department of Pharmacy, Anurag Group Of Institutions,Venkatapur, Medchal, Hyderabad.
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Based on the literature review, we have found that Isatin- Oxadiazole derivatives are exhibiting different activities like anti-oxidant, anti-viral, anti-microbial and anti-convulsant and we synthesized Isatin-Oxadiazole hybrids. Among the series of compounds (E)-5-chloro-3,(2,(5-mercapto-1,3,4-oxadiazol-2yl)hydrazono)-indolin-2-one(IVb), (E)-5-bromo-3,(2,(5-mercapto-1,3,4-oxadiazol-2-yl)hydrazono)-indolin-2-one(IVe) showed most significant antioxidant activity.

  1. Narsimha Reddy Penthala, Thirupathi Reddy Yerramreddy, Bioorganic & Medicinal
Chemistry? Letters 20 (2010) 4468?4471.
  1. Sarangapani, A. Narayan Reddy, Y. Jayamm and V.M. Reddy, Indian Drugs, 35(6) (1998) 336.
  2. Yisheng Lai, Lin Ma, Bioorganic & Medicinal Chemistry Letters, (2010), doi: 10.1016/j.bmcl.2010.10.056.
  3. Braz. chem.Soc, Vol.12, No.3, 273-324,2001 .
  4. J. Bauer and P.W. Sadler, Brit. J. Pharmacol., 15 (1960) 101.
  5. Heinisch, Lothar Ger (East) 113, 531 (Cl Co7d) 12, Jan., 1975, Appl. 168883, 13 Feb. 1973.
  6. Kontz, F., Sci Pharm., 38 (1970) 222; Abstr., 74 (1971) 99770.
  7. N. Pandeya, D. Sriram, G. Nath and E. De Clercq, Eur. J. Pharm. Sci., 9 (1999) 25.
  8. Kontz, F., Sci Pharm., 38 (1970) 222; Abstr., 74 (1971) 99770.
 

[K.Rama Devi, K.S.K Rao Patnaik, D. Ashok, Vasudha Bakshi, Raju Bathula and Satla Shobha Rani. (2017); MICROWAVE IRRADIATION SYNTHESIS AND ANTIOXIDANT ACTIVITY OF ISATIN-OXADIAZOLE DERIVATIVES. Int. J. of Adv. Res. 5 (Jun). 2329-2336] (ISSN 2320-5407). www.journalijar.com

K. RAMA DEVI
University College of Technology, Osmania University,Hyderabad-500007, T.S.

DOI:

Article DOI: 10.21474/IJAR01/4676      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4676

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