31May 2017

STUDY OF SERUM PROTEIN ELECTROPHORESIS IN ELDERLY INDIVIDUALS & ITS CO-RELATION WITH REGARD TO OTHER PARAMETERS.

  • Tutor, AIIMS, Patna.
  • Assistant Professor, Darbhanga Medical College, Laheriasarai, Darbhanga.
  • Professor and Head of Department, Darbhanga Medical College, Laheriasarai, Darbhanga.
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Introduction: Serum protein electrophoresis is used to identify patients with Monoclonal gammopathy including multiple myeloma, Monoclonal gammopathy of undetermined significance (MGUS), polyclonal gammopathies and other related disorders. Electrophoresis separates proteins based on their physical properties, and the subsets of these proteins are used in interpreting the results. Monoclonal gammopathies are associated with a clonal process that is malignant or potentially malignant. The quantity of M protein, the results of bone marrow biopsy, and other characteristics helps in differentiating multiple myeloma from the other causes of monoclonal gammopathy including MGUS. Aim and objective : The aim of this study was (i) to evaluate the elderly individuals (age >50 years) with abnormal serum protein electrophoresis pattern, (ii) to differentiate the various conditions of abnormal serum protein electrophoresis, (iii) to identify and differentiate the cases of monoclonal gammopathies, (iv) to evaluate the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in our part of country & (v) to correlate serum protein electrophoresis pattern with other parameters specially liver function tests and kidney function tests. Materials and methods: This prospective study was carried out in the Department of Pathology, Darbhanga Medical College and Hospital, Laheriasarai. Total 200 elderly individuals of age more than 50 years comprising of equal number of males (100) and females (100) were included in this study. Following proper detailed history and physical examination, venous blood sample was collected with proper aseptic care and serum is obtained after centrifugation. Each serum sample was subjected to total protein estimation and Serum protein electrophoresis. Patients were further evaluated for other parameters e.g., complete blood count (CBC), liver function test, kidney function test, hematological tests and others. Results: Out of 200 cases 28 (14%) cases had abnormal serum protein electrophoresis pattern, of which 3 (1.5%) cases had Monoclonal Gammopathy, 20 (10%) cases had Polyclonal Gammopathy and 2.5% cases had Hypoalbunemia. Among Monoclonal Gammopathy, 2 (1%) cases were of Monoclonal Gammopathy of Undetermined Significance (MGUS) and only one (0.5%) case was of Multiple Myeloma. All 3 cases of Monoclonal gammopathy were of age >60years. The mean age of the individuals in this study group was 62.83 years. The mean age of cases of Monoclonal gammopathy was this study was 69.66 years. Conclusion: In conclusion, Prevalence of Monoclonal Gammopathy, Monoclonal Gammopathy of Undetermined Significance (MGUS) and that of Multiple Myeloma (MM) in our part of the country i.e. North Bihar are 1.5%, 1%, and 0.5% respectively. Prevalence of Multiple Myeloma (MM) and that of Monoclonal Gammopathy of Undetermined Significance (MGUS) in our study does not fall within the ranges given in most of the literature. Prevalence in our study was lower than studies done in other part of the world.

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[Nishi, Talat Fatma and Ajit Kumar Chaudhary. (2017); STUDY OF SERUM PROTEIN ELECTROPHORESIS IN ELDERLY INDIVIDUALS & ITS CO-RELATION WITH REGARD TO OTHER PARAMETERS. Int. J. of Adv. Res. 5 (May). 2145-2157] (ISSN 2320-5407). www.journalijar.com

NISHI
TUTOR, AIIMS, PATNA

DOI:

Article DOI: 10.21474/IJAR01/4363      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4363

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