27May 2017

SYNTHESIS AND CHARACTERIZATION OF PROP-2-YN-1-YL 3-(2-(1,3-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-1H-PYRROLO[3,2-D]PYRIMIDIN-5(2H)-YL)ACETAMIDO)-2,2-DIMETHYLPROPANOATE AND PENT-4-YN-1-YL 3-(2-(1,3-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-1H-PYRROLO[3,2-D]PYRIMIDIN-5(2H)-YL)ACETAMIDO)-3-METHYLBUTANOATE.

  • Dravidian University, Srinivasa vanam, Kuppam-517426, Chittor, Andhra Pradesh.
  • Department of organic chemistry, Andhra University, Waltair, Visakhapatnam-530003 Andhra Pradesh.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

The synthesis of some pyrrolo[3,2-d]pyrimidine compounds is described. They were prepared from 3-((tert-butoxycarbonyl)amino)-2,2-dimethylpropanoic acid in a series of steps by conventional method by using simple reagents and its exhibits biological activity

  1. Wang, X.; Seth, P. P.; Ranken, R.; Swayze, E. E.; Migawa, M. T. Nucleosides, Nucleotides Nucleic Acids 2004, 23, 161.
  2. Henderson, J. F.; Paterson, A. R. P.; Caldwell, I. C.; Paul, B.; Chan, M. C.; Lau, K. F. Cancer Chemother. Rep. 2 1972, 3, 71.
  3. Cook, A. F.; Holman, M. J. Nucleosides Nucleotides 1984, 3, 401.
  4. Hinshaw, B. C.; Gerster, J. F.; Robins, R. K.; Townsend, L. B. J. Heterocyclic. Chem. 1969, 6, 215.
  5. Bhattacharya, B. K.; Rao, T. S.; Revankar, G. R. J. Chem. Soc., Perkin Trans. 1 1995, 1543.
  6. Ojwang, J. O.; Bhattacharya, B. K.; Marshall, H. B.; Korba, B. E.; Revankar, G. R.; Rando, R. F. Antimicrobial Agents Chemotherapy. 1995, 39, 2570.
  7. Bhattacharya, B. K.; Ojwang, J. O.; Rando, R. F.; Huffman, J. H.; Revankar, G. R. J. Med. Chem. 1995, 38, 3957.
  8. Seela, F.; Thomas, H. Helv. Chim. Acta 1995, 78, 94.
  9. Seela, F.; Zulauf, M. Chem. Eur. J. 1998, 4, 1781.
  10. Ramzaeva, N.; Seela, F. Helv. Chim. Acta 1996, 79, 1549.
  11. Balow, G.; Mohan, V.; Lesnik, E. A.; Johnston, J. F.; Monia, B. P.; Acevedo, O. L. Nucleic Acids Res. 1998, 26, 3350.

[Sridhar Prasangi, Desireddy Srinivas reddy and YLN Murthy. (2017); SYNTHESIS AND CHARACTERIZATION OF PROP-2-YN-1-YL 3-(2-(1,3-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-1H-PYRROLO[3,2-D]PYRIMIDIN-5(2H)-YL)ACETAMIDO)-2,2-DIMETHYLPROPANOATE AND PENT-4-YN-1-YL 3-(2-(1,3-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-1H-PYRROLO[3,2-D]PYRIMIDIN-5(2H)-YL)ACETAMIDO)-3-METHYLBUTANOATE. Int. J. of Adv. Res. 5 (May). 1260-1263] (ISSN 2320-5407). www.journalijar.com

sridharprasangi
1Dravidian University, Srinivasa vanam, Kuppam-517426, Chittor, Andhra Pradesh

DOI:

Article DOI: 10.21474/IJAR01/4241      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4241

Download Full Paper

Download PDF No. of Downloads: 25 | No. of Views: 95