25Apr 2017

CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITY OF PAJANELIA LONGIFOLIA (WILLD.) K.SCHUM AGAINST MULTI DRUG RESISTANT CLINICAL ISOLATES FROM DIABETIC FOOT ULCER.

  • Division of Microbiology, Rajah Muthiah Medical College, Annamalai University, Tamilnadu, India.
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Antibiotic drug resistance has lead to the need for alternate treatment strategies and recently paid attention to extracts and biologically active compounds isolated from plant species. The present study performed phytochemical screening and GC-MS analysis to identify the possible presence of various phytochemical constituents present in the Petroleum ether, Ethyl acetate, Ethanol and Aqueous leaf extracts of P. longifolia. The antibacterial activity was evaluated by disc diffusion and MIC/MBC assays against Multi drug resistant bacterial isolates from DFU and ATCC bacterial strains. The phytochemical screening of leaves extracts proved the occurrence of diverse phytochemicals and GC-MS analysis identified presence of major compounds Phytols (36.37-52.17%), Flavones (13.50%), Esters (9.18-20.01%), Carboxylic acids (4.76%). Ethyl acetate, ethanol extracts of the plant showed potential antibacterial activity against P. aeruginosa ATCC 27853, S. aureus ATCC 29213, MDR- MRSA, MDR- P. aeruginosa, MDR- E. coli, MDR- A. baumanii. From this study, it can be concluded that leaves of and Pajanelia longifolia (Willd.) K Schuman has potential antibacterial compounds that may be used for developing new drugs against multiple drug resistant pathogenic bacteria.

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[Katherin Steffy, G. Shanthi and V. Natarajan. (2017); CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITY OF PAJANELIA LONGIFOLIA (WILLD.) K.SCHUM AGAINST MULTI DRUG RESISTANT CLINICAL ISOLATES FROM DIABETIC FOOT ULCER. Int. J. of Adv. Res. 5 (Apr). 907-915] (ISSN 2320-5407). www.journalijar.com

Katherin Steffy
Division of Microbiology, Rajah Muthiah Medical College, Annamalai University, Tamilnadu, India

DOI:

Article DOI: 10.21474/IJAR01/3894      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3894

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