23May 2017

STUDY THE ADVERSE EFFECTS OF EXPOSURE TO LEAD ACETATE ON MICE OVARIAN TISSUE.

  • Department of Molecular Genetics and Finger Printing, Forensic DNA Centre for Research and Training, Al-Nahrain University- Baghdad, Iraq.
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There has been growing concern about human reproductive perturbation by xenobiotics encompass drugs, occupational, and environmental exposures of toxicant. Lead considered as one that could affect the gonadal structure and functions. Exposure to lead is still a major medical dilemma in both environmental and occupational settings. The toxicity of lead, on adult female reproduction results in reduce fertility, less ability to sustain pregnancy, and low pregnancy outcomes. As there is an increase usage of electrical generators that depend on lead-based gasoline by Iraqi people which lead to increase the air pollution with this toxic substance induced me to detect through this study its possible negative effects on the ovarian tissue using the mouse as a model. Albino mice of 8-10 weeks age weighing between 25-30 grams divided randomly into two groups of 16 each. The first group (control group) (c), was not given lead acetate whereas group II were given lead acetate in dose 0.3 mg /kg BW. / Day, intraperitoneally, for 14 days. Animals of each group scarified to get their ovaries which removed by dissection, processed with the standard histopathological technique for the quantitative assessment of follicle numbers and to study the histological changes in the ovarian tissue. The result of this study revealed thatlow dose of lead acetate injected to mature female mice intraperitoneally for 14 days cause a non-significant decrease in the number of follicles. But ovaries belong to experimental group revealed histopathological alterations in the various components of their ovaries.This study designed to detect the possible deleterious effect oflow dose of lead acetate on the ovarian tissue of mature female mice.

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[Ibtisam Jasim Sodani (2017); STUDY THE ADVERSE EFFECTS OF EXPOSURE TO LEAD ACETATE ON MICE OVARIAN TISSUE. Int. J. of Adv. Res. 5 (May). 727-735] (ISSN 2320-5407). www.journalijar.com

Ibtisam Jasim Sodani
Al-Nahrain University, Baghdad, Iraq

DOI:

Article DOI: 10.21474/IJAR01/4171      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4171

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