25Apr 2017

SIGNIFICANCE OF VITAMIN -D AND INSULIN RESISTANC IN POLYCYSTIC OVARIAN SYNDROME IN MANIFESTING RHEUMATOID ARTHRITIS.

  • Department Of Biochemistry Ph.D scholar Saveetha University, Chennai, Tamilnadu, India.
  • Department Of Biochemistry , Saveetha University, Chennai, Tamilnadu, India..
  • Director Of Research, Saveetha University, Chennai, Tamilnadu, India.
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Aim& objectives: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder; It is a heterogeneous androgen excess disorder with different degrees of reproductive and metabolic dysfunctions. The objective of this study is to determine whether serum vitamin D and insulin resistance manifest to Rheumatoid Arthritis in women with PCOS are not. Materials and methods:- The study includes total of 80 Subjects within the age group of 20 to 50years were selected and divided into two groups. Group I consisted of 50 diagnosed female patients of PCOD. 5 ml of blood sample was obtained from the participant under all aseptic precautions after 12 hours of fasting . 2ml is transferd to EDTA and ramaing blood in plain tubes allowed to clot at 1 hour and centrifuged at 2000rpm for 10mits to obtain serum. The Serum samples are collected for estimation of is glucose ,Insulin , vitamin D , insulin resistance index (HOMA - IR),and anti ?ccp are analysed Results: Women with PCOS had significantly higher FBS(112?15.9) (P<0.01) than the control subjects(83.30?11.95), Women with PCOS had significantly higher insulin values (23?.9) (P<0.01) than the control subjects(83.30?11.95), Women with PCOS had significantly higher HOMA-IR(112?15.9) (P<0.01) than the control subjects(83.30?11.95), Women with PCOS had significantly higher VITAMIN -D(112?15.9) (P<0.01) than the control subjects(83.30?11.95). Conclusion: Vitamin D is not only a regulator of bone and mineral metabolism, but also a potent immunomodulator linked to many major human diseases including glucose homeostasis and insulin resistance. Insulin resistance encourages oxidative stress because hyperglycemia and higher levels of free fatty acids lead to ROS production. Thus, insulin may defend against pro-inflammatory responses to hyperglycemia by acting as an anti-inflammatory agent. Proinflammatory cytokines seem to have beneficial effects on the insulin resistance observed in patients with RA and hormonal mechanisms involved in RA.

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[T.Uma, D.S.S.Girija Vani and R. Vijayaraghavan. (2017); SIGNIFICANCE OF VITAMIN -D AND INSULIN RESISTANC IN POLYCYSTIC OVARIAN SYNDROME IN MANIFESTING RHEUMATOID ARTHRITIS. Int. J. of Adv. Res. 5 (Apr). 1226-1232] (ISSN 2320-5407). www.journalijar.com

T.UMA
Department Of Biochemistry Ph.D scholar Saveetha University, Chennai, Tamilnadu, India

DOI:

Article DOI: 10.21474/IJAR01/3938      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3938

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