29Mar 2017

KINETICS AND MECHANISM OF THE HYDROLYSIS OF 4-HYDROXYBIPHENYL PHOSPHATE MONOESTER.

  • Cadila Pharmaceutical, Ahmedabad.
  • Christ Church College, Kanpur.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Hydrolysis of 4-hydroxybiphenyl phosphate monoester has been carried out in acid (HCl) Solution at 97± 0.50 C and the inorganic phosphate obtained during hydrolysis has been estimated coloremetrically . Pseudo first order rate coefficients have been calculated neutral and conjucated acid species have been found to be reactive and contributed to the overall hydrolysis in the acid region. The calculated rate coefficients are in good agreement with the experimentally observed ones. The effect of temperature, solvent and substrate concentration on the rate of hydrolysis have been studied. The results suggest that the hydrolysis of monoester occurs by the cleavage of P-O bond fission.

  1. Humphy ,T.M; Forconi Marcello, Willam Nicholos; Hengge, H.C; J of American Chemical Soc. 124(50) 14860-14861 (2002).
  2. R; Dixit,V.K; Agarwal,A;Parihar,P.S; Asian J of Chemistry Vol (XVI)3758 (2008).
  3. R; Chand,S; Global J for Research analysis Vol.4(8) pg 13-16(2015).
  4. M.M; Patwardhan,M.D; & Kasturi,G; Indian J of Chem;7:149(1969)
  5. Mhala,M.M; Jagdale,M.H; Indian J of Chem.8,147(1970)
  6. Mhala,M.M;Kushwaha,R.S;. Indian J of Chem Pub.No.3/4 Sec.A 4263A-H(1989).
  7. Jacklak,C.K; Ph.D. Thesis Jiwaji University, Gwalior(1972).
  8. Tiwari,B.K; Kushwaha,R.S; J of Science Shivaji University Kolhapur Vol.23(1986).
  9. Banard,P.W.C;Bunton,C.A;Killerman,D;Mhala,M.M;Silver,C.A;Vermon;& Welch,V.A;J.Chem.Soc.B227(1966).
  10. Chaudhary,S;Ph.D;Thesis Jiwaji university , Gwalior(1994).
  11. Mhala,M.M;Ph.D.Thesis London(1958).
  12. Tiwari,B.K;David,S;Solonki,A;Kanta;Asian J of Chemistry.Vol.14(1)39-52(2002).
  13. Rudert,P;J.Chem.Soc.a.1:323-324(1993).
  14. Debey & Huckel,Physic,Z;24,185-305(1923).
  15. Barnard,P.W.C;Bunton,C.A;Killerman.D;Mhala,M.M;Silver,B;J.Chem.Soc;Sec-B,227-235(1996).
  16. Bronsted,J.N.Z;Physik,Chem 102,169(1992),115,237(1925).
  17. Bjerrum,N;Z.Physik.Chem;108,82(1924),118,251(1925).

[Ruchi Singh And Shweta Chand. (2017); KINETICS AND MECHANISM OF THE HYDROLYSIS OF 4-HYDROXYBIPHENYL PHOSPHATE MONOESTER. Int. J. of Adv. Res. 5 (Mar). 1354-1361] (ISSN 2320-5407). www.journalijar.com

Dr. Shweta Chand
Asstt. Professor, Christ Church College Kanpur

DOI:

Article DOI: 10.21474/IJAR01/3643      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3643

Download Full Paper

Download PDF No. of Downloads: 26 | No. of Views: 115